CAS: 4090-18-0; Sinoacutine

上下游产品

(S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4,4-dimethoxy-cyclohex-2-enylmethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 4,4-Dimethoxy-3-oxo-cyclohexanecarboxylic acid ethyl ester (3-Bromomethyl-6,6-dimethoxy-cyclohex-1-enyloxy)-tert-butyl-dimethyl-silanethebaine

📜6,7-二甲氧基-1,2,3,4-四氢异喹啉置于四氯化锡,2,3-二氯-5,6-二氰基-1,4-苯醌,Lithium Diisopropyl Amide体系中,化学反应生成 清风藤碱
参考文献:Ludwig,Wolfgang; Schaefer,Hans J.,Angewandte Chemie,1986,Vol. 98,# 11,P. 1032-1033
标题:Ludwig,Wolfgang; Schaefer,Hans J.,Angewandte Chemie,1986,Vol. 98,# 11,P. 1032-1033

专利信息

专利号:US-3894027-A
优先权日:1973-07-31
标 题:Resolution of racemic reticuline and racemization of its enantiomers
发明人：SOHAR PAUL; SCHOENEWALDT ERWIN F
权利人:MERCK & CO INC
摘要:Racemic reticuline is resolved by forming a crystalline diastereomeric acid salt with a mandelic acid enantiomer. The reticuline enantiomers are racemized by treatment with a reduced noble metal or noble metal oxide catalyst. (-)-Reticuline is a valuable intermediate useful in the synthesis of thebaine, and (+)-reticuline is useful as a precursor of pallidine, sinoacutine, coreximine, and the berberine alkaloids.

专利号:US-8557837-B2
优先权日:2010-02-10
标题:Sinomenine derivatives, synthetic methods and uses thereof
发明人：YAO ZHUJUN; SUN BING; LOU YANGTONG; YANG ZHENYU; CHEN AIZHONG; MA ZHAO
权利人:YAO ZHUJUN; SUN BING; LOU YANGTONG; YANG ZHENYU; CHEN AIZHONG; MA ZHAO; SHANGHAI INST ORGANIC CHEM; SHANGHAI INST BIOL SCIENCES
摘要:The invention relates to sinomenine derivatives, methods for their synthesis and their applications. The sinomenine derivatives include oxidation derivatives, and C-10 substituted sinomenine derivatives. Based on the readily oxidizable phenol group on sinomenine structure, using oxidation, oxidative dearomatization, or conjugated addition aromatization, one can introduce C-10 substitutions to synthesize the sinomenine derivatives. The sinomenine derivatives of the invention have the following structures: n n n n n n n n n n Using in vitro TNF-α inhibition assay, the activities of the synthetic compounds are assessed. Results from these assays shown that most compounds have anti-inflammatory effects, and some compounds have better activities than that of sinomenine. These compounds may be used in treating immune diseases such as rheumatoid arthritis (RA).

专利号:CN-101798285-A
优先权日:2010-02-10
标 题:A kind of sinomenine derivative, synthesis method and application thereof

专利号:CN-101798285-B
优先权日:2010-02-10
标 题 :A kind of sinomenine derivative, synthesis method and application thereof