CAS: 38183-12-9; 4-Phenyl-3H,3'H-Spiro[furan-2,1'-Isobenzofuran]-3,3'-Dione

📜在 Sodium Periodate体系中,用 水 作为反应溶剂,化学反应 8.0H,以96%的收率获得产物荧光胺
参考文献:一种制备荧光胺的工艺方法
标题:一种制备荧光胺的工艺方法
摘要:本发明公开了一种制备荧光胺的工艺方法,包括以下步骤:步骤一:以茚三酮为原料,与苯乙醛在适量催化剂催化下,反应得到三环中间体;步骤二:以三环中间体为原料,在适量氧化剂氧化下,反应得到荧光胺.其合成路线短,工艺简单,反应条件温和,反应收率高.

专利信息

专利号:US-4105651-A
优先权日:1976-03-15
标 题:Purification of enkephalin, an endogenous composition in the human body and synthesis of same
发明人：HUGHES JOHN
权利人:US HEALTH EDUCATION & WELFARE
摘要:The purification of an endogenous composition isolated from mammalian brain tissue and termed enkephalin ('in the head'). Enkephalin is recovered from brain tissue by acetone solution and purified by means of column and thin layer chromatography. The composition which is a mixture of two pentapeptides, namely, (a) H-Tyr-Gly-Gly-Phe-Met-OH and (b) H-Tyr-Gly-Gly-Phe-Leu-OH wherein the ratio of a:b is from 3:1 to 4:1 has been found to be a non-addictive narcotic and an opiate agonist. n The synthesis of the pentapeptide composition from the known structure above is accomplished by conventional solution techniques of protection of the amino groups, such as t-butyloxycarbonyl, benzyloxycarbonyl, and t-amyloxycarbonyl, or the solid phase peptide synthesis of R. Bruce Merrifield using a polymeric support and the same or similar amine protecting groups.

专利号:US-2007122842-A1
优先权日:2005-11-30
标题 :Massively parallel synthesis of proteinaceous biomolecules
发明人：RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
权利人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.

专利号:US-4242256-A
优先权日:1977-03-15
标 题 :Synthesis of peptide analogues
发明人：SHARPE ROBERT; SZELKE MICHAEL
权利人:SHARPE ROBERT; SZELKE MICHAEL
摘要:Compounds being analogues of a dipeptide in which the nitrogen atom of the linking amide group of the dipeptide is replaced by trivalent group ##STR1## and in which, optionally, the carbonyl function of this linking group is replaced by the divalent group --CH 2 -- are of value in the synthesis of isosterically modified peptides.

专利号:US-2007122841-A1
优先权日:2005-11-30
标题:Massively parallel synthesis of proteinaceous biomolecules
发明人：RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
权利人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.

专利号:WO-9000622-A1
优先权日:1988-07-08
标题 :Oligonucleotide hybridization probes and means for the synthesis of the most preferred probes
发明人：KWIATKOWSKI MAREK; SUND CHRISTIAN; HURSKAINEN PERTTI
权利人:WALLAC OY; PHARMACIA AB
摘要:Oligonucleotide probe labeled at one of its teminal positions with a non-linear branched polymer carrying a plurality of negatively charged groups, preferably phosphodiester groups, and optionally also analytically indicatable groups covalently linked to terminal ends of the branches of said polymer. The preferred indicatable groups are lanthanide chelates. A compound that can be used for the synthesis of the probe is also disclosed. The compound has formula (I), where R1 and R2 are lower alkyl; R3 is lower alkyl (C1-C7), or aryl each of which optionally being provided with electron-withdrawing substituents; and A1, A2 and A3 are hydrogen, A'-O-B, A''-O-B or A'''-O-B, at most one of A1-3 being hydrogen and A', A'' and A''' being a hydrocarbon chain providing a distance of 5-9 atoms between the phosphorous atom and the oxygen directly bound to B, and B being a protecting group. In the preferred compound at least two of A1-3 are identical while the other is hydrogen.

专利号:US-9499578-B2
优先权日:2005-12-29
标题 :Massively parallel synthesis of biopolymeric arrays
发明人：RAJASEKARAN JOHN J; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; TIWARI GUNJAN
权利人:RAJASEKARAN JOHN J; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; TIWARI GUNJAN; INTEL CORP
摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.