CAS: 24397-89-5; Actinobolin
- 英文名称Actinobolin
- 中文名称肌动蛋白
- IUPAC名称(S)-2-amino-N-((3R,4R,4aR,5R,6R)-5,6,8-trihydroxy-3-methyl-1-oxo-3,4,4a,5,6,7-hexahydro-1H-isochromen-4-yl)propanamide
- 其它别名Propanamide, 2-Amino-N-(3,4,4A,5,6,7-Hexahydro-5,6, 8-Trihydroxy-3-Met Hyl-1-Oxo-1H-2-Benzopyran-4-yl)-; Actinobolin; (3R)-4α-[[(S)-2-Aminopropanoyl]Amino]-3,4,4Aβ,5,6,7-Hexahydro-5β,6α,8-Trihydroxy-3α-Methyl-1H-2-Benzopyran-1-One; (S)-2-Amino-N-[(3R)-3,4,4Aβ,5,6,7-Hexahydro-5β,6α,8-Trihydroxy-3α-Methyl-1-Oxo-1H-2-Benzopyran-4α-Yl]Propanamide; (S)-2-Amino-N-[(3R,4R,4Ar,5R,6R)-3,4,4A,5,6,7-Hexahydro-5,6,8-Trihydroxy-3-Methyl-1-Oxo-1H-2-Benzopyran-4-Yl]Propanamide; (S)-N-[(3R)-3,4,4Aβ,5,6,7-Hexahydro-5β,6α,8-Trihydroxy-3α-Methylisocoumarin-4α-Yl]-2-Aminopropionamide; Propanamide, 2-Amino-N-[(3R,4R,4Ar,5R,6R)-3,4,4A,5,6,7-Hexahydro-5,6,8-Trihydroxy-3-Methyl-1-Oxo-1H-2-Benzopyran-4-Yl]-, (2S)-
- CAS编号24397-89-5
- MFCD编号:MFCD01718124
- FDA UNII编号:999317A21F
- 分子式:C13H20N2O6分子量:300.31
- 产品CID: 1191372
- 产品分类有机原料→分子砌块→桥环类化合物→其它桥环类化合物
相似化合物
130525-62-1物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
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专利信息
专利号:US-8222434-B1
优先权日:2009-04-04
标 题 :Bactobolin analog and synthesis method thereof
发明人：GREENBERG E PETER; CHANDLER JOSEPHINE R; DUERKOP BRECK; LIMA PATRICIA SILVA; BLODGETT JOSHUA ALAN; CLARDY JON; SEYEDSAYAMDOST MOHAMMAD R
权利人:GREENBERG E PETER; CHANDLER JOSEPHINE R; DUERKOP BRECK; LIMA PATRICIA SILVA; BLODGETT JOSHUA ALAN; CLARDY JON; SEYEDSAYAMDOST MOHAMMAD R; UNIV WASHINGTON CT COMMERCIALI; HARVARD COLLEGE
摘要:The present inventions are directed to a novel bactobolin analog bactobolin D. The present inventions also are directed to a method of producing a composition comprising at least one bactobolin analog using a bacteria strain comprising a bacterial cell comprising the biosynthetic locus of the bactobolin analog in Burkholderia thailandensis (bta cluster) or a homolog structure (at least 95% sequence identity) thereof, and further isolation and purification of the bactobolin analog. For example, the bacterial strain can be a wild type bacterial strain such as a Burkholderia strain comprising a bta cluster (e.g. Burkholderia thailandensis (e.g. E264, Bt4, and TXDOH) and Burkholderia pseudomallei (e.g. K96243, 1106a, and 1106b).
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合成参考文献
摘要:National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program., JAN1986
摘要:PITTILLO RF, SCHABEL FM, QUINNELLY BG. Studies on the antimicrobial nature of action of actinobolin. Antibiot Chemother (Northfield). 1961 Aug;11():501–11.
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