CAS: 23234-43-7; H-D-Tyr-Oet.Hcl

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4-(2-Methyl-2-Phenylpropyloxy)Aniline置于palladium On Activated Charcoal Copper(I) Oxide,盐酸,Sodium Hydroxide,Sodium Azide,乙醚,水,氢气,三溴化硼,丙烯酸乙酯,Sodium Nitrite体系中,用 甲醇,二氯甲烷,水,二甲基亚砜 用作溶剂,化学反应 9.33H,反应生成D-酪氨酸乙酯盐酸盐
参考文献:Kawamatsu; Asakawa; Saraie,Arzneimittel-Forschung/drug Research,1980,Vol. 30,# 5,P. 751-758
标题:Kawamatsu; Asakawa; Saraie,Arzneimittel-Forschung/drug Research,1980,Vol. 30,# 5,P. 751-758

专利信息

专利号:US-11806326-B2
优先权日:2018-01-29
标 题 :Methods for dopamine modulation in human neurologic diseases
发明人：SACKNER-BERNSTEIN JONATHAN
权利人:SACKNER BERNSTEIN JONATHAN
摘要:A method of treating Parkinson's Disease, Huntington's Disease and the like, diseases with abnormal dopamine-neuro-transmission, using small molecules administered systemically that penetrate into the central nervous system to inhibit the rate-limiting step of dopamine synthesis in the central nervous system, the conversion of L-tyrosine to L-3, 4-dihydroxyphenylalanine (L-DOPA) by tyrosine hydroxylase along with its cofactors tetrahydrobiopterin and iron (Fe+).