CAS: 2135-17-3; Flumethasone

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CAS号23961-95-7 9beta,11beta-ep... | CAS号2002-29-1 特戊酸氟米松 | CAS号4571-51-1 9β,11β-epoxy-6α... | CAS号2607-06-9 双氟可龙 | CAS号28416-82-2 氟米松酸

(6Alpha,9Beta,11Beta,16Alpha)-9,11-环氧-6-氟-17,21-二羟基-16-甲基-孕甾-1,4-二烯-3,20-二酮置于氢氟酸体系中,化学反应 5.0H,反应生成氟米松
参考文献: Process For The Preparation Of 17-Desoxy-Corticosteroids[fr] Procédé De Préparation De 17-Désoxy-Corticostéroïdes
标题: Process For The Preparation Of 17-Desoxy-Corticosteroids[fr] Procédé De Préparation De 17-Désoxy-Corticostéroïdes
摘要:本发明提供了一种改进的方法,通过将17-羟基起始物与过量的碘化三甲基硅烷反应,在单一化学步骤中制备17-去氧皮质类固醇衍生物.本发明在制备具有卤素基团的17-去氧皮质类固醇衍生物方面具有明显优势,这些卤素基团位于皮质类固醇的2,6,7或9位,例如氯科尔酮或去氧美他松.

专利信息

专利号:US-7208613-B2
优先权日:2002-06-20
标 题:Synthesis of s-fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate
发明人：JADAV KANAKSINH JESINGBHAI; KAMBHAMPATI SUDHAKAR; CHITTURI TRINADHA RAO; THENNATI RAJAMANNAR
权利人:SUN PHARMACEUTICAL IND LTD
摘要:The present invention provides a convenient process for the preparation of S-fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate, a compound of formula 1, comprisingn (a) treating 17β-[(N,N-dimethylcarbamoyl)thio]carbonyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene, a compound of formula 3 with alkali metal carbonate-alcohol system to obtain 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioic acid, a compound of formula 4; (b) reacting the compound of formula 4 with bromofluoromethane to yield the compound of formula 1.

专利号:US-10954265-B2
优先权日:2016-10-14
标 题 :Structures and mechanism for the design of highly potent glucocorticoids
发明人：XU HUAQIANG ERIC; HE YUANZHENG
权利人:VAN ANDEL RES INSTITUTE
摘要:The present invention relates to novel glucocorticoid compounds. The invention also relates to methods of using these compounds, the synthesis of these compounds, and to compositions and formulations comprising the glucocorticoid compounds, and uses thereof.

专利号:US-9975918-B2
优先权日:2013-09-25
标 题:Highly potent glucocorticoids
发明人：XU HUAQIANG ERIC; HE YUANZHENG; MELCHER KARSTEN; YI WEI; SHI JINGJING
权利人:VAN ANDEL RES INSTITUTE; SHANGHAI INST MATERIA MEDICA CAS
摘要:The present invention relates to novel glucocorticoid compounds. The invention also relates to methods of using these compounds, the synthesis of these compounds, and to compositions and formulations comprising the glucocorticoid compounds, and uses thereof.

专利号:US-2005256325-A1
优先权日:2002-06-20
标题:Convenient synthesis of s-fluoromethyl 6alpha, 9alpha-difluoro-11beta-hydroxy-16alpha-methyl-17alpha-propionyloxy-3-oxoandrosta-1,4-diene-17beta-carbothioate