CAS: 2098457-92-0; 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-Oxopiperidin-1-yl)Phenyl)-7-Oxo-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide

英文名称1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-Oxopiperidin-1-yl)Phenyl)-7-Oxo-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide
中文名称1-(4-甲氧基苯基)-6-[4-(2-甲基-6-氧代哌啶-1-基)苯基]-7-氧代-4,5-二氢吡唑并[3,4-c]吡啶-3-甲酰胺
IUPAC名称1-(4-methoxyphenyl)-6-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
其它别名Apixaban-7; 1-(4-Methoxyphenyl)-6-[4-(2-Methyl-6-Oxopiperidin-1-yl)Phenyl]-7-Oxo-4,5-Dihydropyrazolo[3,4-C]Pyridine-3-Carboxamide; Apixaban Impurity 4/1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-Oxopiperidin-1-yl)Phenyl)-7-Oxo-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide; 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-Oxopiperidin-1-yl)Phenyl)-7-Oxo-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide; 1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide, 4,5,6,7-Tetrahydro-1-(4-Methoxyphenyl)-6-[4-(2-Methyl-6-Oxo-1-Piperidinyl)Phenyl]-7-Oxo-
CAS编号2098457-92-0
MFCD编号:MFCD27996060
FDA UNII编号:8SRS89L6ZQ
分子式:C26H27N5O4
分子量:473.53
产品CID: 1085276
产品分类有机原料 → 有机杂环化合物 → 哌啶类

相似结构搜索
InChIKey: BDNVCXVQYXUHCR-UHFFFAOYSA-N
InChI=1S/C26H27N5O4/c1-16-4-3-5-22(32)30(16)18-8-6-17(7-9-18)29-15-14-21-23(25(27)33)28-31(24(21)26(29)34)19-10-12-20(35-2)13-11-19/h6-13,16…
计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数5.0

MSDS等安全信息

上下游产品

1-(4-iodo-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one -caprolactam ethyl 5-oxohexanoate 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one

合成工艺路线路线简述

1-(4-碘苯基)-3-吗啉基-5,6-二氢吡啶-2(1H)-酮在 Cubr(Pph3)3,Sodium Methylate,Caesium Carbonate,Formamide,三乙胺体系中,用甲醇,二氯甲烷,氯仿作为反应溶剂,反应 203.5H,获得 Apixaban
参考文献:一种阿哌沙班有关物质,中间体,制备方法及其应用
标题:一种阿哌沙班有关物质,中间体,制备方法及其应用
摘要:本发明公开了一种阿哌沙班有关物质,中间体,制备方法及其应用.本发明提供了一种阿哌沙班有关物质i及其制备方法,包括以下步骤:有机溶剂中,甲醇钠存在的条件下,将化合物ii与甲酰胺进行酰胺化反应,得到阿哌沙班有关物质i.本发明的合成方法收率较高,方便阿哌沙班制备过程中的后续质量控制研究.