CAS: 20559-16-4; (R)-2-Hydroxy-3-(Tetradecanoyloxy)Propyl (2-(Trimethylammonio)Ethyl) Phosphate

相似化合物

19420-57-6 17364-16-8 20559-18-6

上下游产品

dimyristoylphosphatidylcholine 1,2-dimyristoyl-sn-glycero-3-phosph°Choline bisundecanoyl>-sn-glycero-3-phosph°Choline1,1'-dimyristoyl-2,2'-11,11'-bisundecanoyl-sn-glycero-3-phosph°Choline

二肉豆蔻酰磷脂酰胆碱置于tris-Hcl Buffer,Calcium Chloride,Phospholipase A2体系中,用 乙醚,乙醇 用作溶剂,化学反应 19.0H,以78.6%的收率获得1-肉豆蔻-Sn-甘油-3-磷酸胆碱
参考文献:γ-Ray Irradiation Of Liposomes Of Polymerizable Phospholipids Containing octadeca-2,4-Dienoyl Groups And Characterization Of The Irradiated Liposomes
标题:γ-Ray Irradiation Of Liposomes Of Polymerizable Phospholipids Containing octadeca-2,4-Dienoyl Groups And Characterization Of The Irradiated Liposomes
摘要:本文描述了含有十八碳-2,4-二烯酰基团在2-酰基链上的多种可聚合磷脂的合成以及含有这些磷脂的脂质体在γ辐照下的特性.我们合成了三种不同类型的可聚合磷脂酰胆碱,它们具有不同长度的1-酰基链和2-酰基链上的十八碳-2,4-二烯酰基团:肉豆蔻酰(modpc),棕榈酰(podpc)和硬脂酰(sodpc).脂质体通过0.2微米孔径的聚碳酸酯滤器挤压制备,并通过不同剂量率的γ辐照进行聚合.聚合速率按sodpc > Modpc > Podpc的顺序增加.Sodpc的聚合机制与1,2-双[(E,E)-十八碳-2,4-二烯酰]-Sn-甘油-3-磷脂酰胆碱(dodpc)相同,但与modpc和podpc不同.通过冷冻-解冻测试评估了可聚合脂质体的稳定性.Modpc脂质体比其他单功能脂质体更稳定.对于类似的辐照,脂质体的聚合行为受到1-酰基长度的显著影响.
Doi:10.1039/a908732J

专利信息

专利号:US-2018312534-A1
优先权日:2015-10-16
标题:Fluorescent anticancer platinum drugs
发明人：SARKAR ARINDAM; MANDAL SWADHIN KUMAR; SENGUPTA ANIRUDDHA; BISWAS GOUTAM; DUTTA PRADIP; SHARMA RUPALI; RAJ JUSTIN PAUL; SURYAVANSHI HEMANT; KUMARI SMITA
权利人:INVICTUS ONCOLOGY PVT LTD
摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.

专利号:US-10730899-B2
优先权日:2013-06-14
标 题 :Lipid-based platinum compounds and nanoparticles
发明人：SENGUPTA SHILADITYA; ROY MONIDEEPA; SARKAR ARINDAM; HOSSAIN SK SAMAD; SENGUPTA ANIRUDDHA; DUTTA PRADIP; ANSARI AASIF
权利人:AKAMARA THERAPEUTICS INC
摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corresponding nanoparticles thereof. The disclosure further relates to synthesis of said platinum based compounds, nanoparticles and compositions comprising said platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by employing aforesaid carbene compounds, platinum based compounds, nanoparticles and compositions thereof.

专利号:WO-2024107474-A1
优先权日:2022-11-15
标 题 :Controlled lipid self-assembly for scalable manufacturing of next-generation immune stimulating complexes
发明人：IRVINE DARRELL; HAMMOND PAULA; PIRES IVAN SUSIN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Methods of controlled lipid self-assembly for scalable manufacturing of next-generation immune stimulating complexes (ISCOMs) are described. The methods involve mixing one or more saponins, one or more lipids, one or more sterols, one or more additional adjuvants (e.g., TLR4 agonist), and optionally one or more antigens in the presence of a detergent. Typically, the mixing step is followed by an incubation step, a dilution and/or concentration step, and/or a filtration or dialysis step for removing detergent. Preferably, methods involve a tangential flow filtration (TFF) process suitable for scalable synthesis and Good Manufacturing Practice (GMP) production of highly homogeneous clinical-grade ISCOM-based adjuvants.