CAS: 1984-65-2; 1,3-Dichloro-2-Methoxybenzene

该化合物是一种有机化合物,其特点是其芳香结构,其特点是一个甲氧基组(-OCH)和两个氯原子,位于苯环的2和6个位置,其分子式为CHCLO,并被归类为的氯化衍生物.该化合物一般是无色的,可粉色黄色液体,有独特的杂质,经常与葡萄酒和其他饮料的污点有关. 2,6-二氯硝醇以其水溶性低而闻名,但更易溶于有机溶剂,主要形成于某些农药降解的副产品,也可能来自的氯化,该化合物因其持久性及其对食品和饮料质量的潜在影响,对环境化学具有兴趣.此外,还研究了该化合物在各种产品的感知特性中的作用,特别是在酒中的碳污染方面.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号87-65-0 2,6-二氯苯酚 | CAS号77-78-1 硫酸二甲酯 | CAS号87-40-1 2,4,6-三氯苯甲醚 | CAS号87-61-6 1,2,3-三氯苯 | CAS号67-56-1 甲醇 | CAS号124-41-4 甲醇钠 | CAS号108-95-2 苯酚 | CAS号100-66-3 苯甲醚 | CAS号37908-97-7 3,5-二氯-4-甲氧基苯甲酸 | CAS号115382-33-7 2,4-二氯-3-甲氧基苯甲酸 | CAS号25319-98-6 3,5-二氯-4-羟基苯磺酸 | CAS号118795-79-2 2,6-dichloroani... | CAS号87-65-0 2,6-二氯苯酚 | CAS号766-51-8 邻氯苯甲醚 | CAS号100-66-3 苯甲醚 | CAS号20103-10-0 2,6-二氯-1,4-氢化喹啉 | CAS号75422-27-4 1,3-dichloro-4-... | CAS号77102-92-2 3-氯-2-甲氧基苯酚

合成工艺路线路线简述

    苯甲醚 反应生成2,6-二氯苯甲醚
    参考文献:Jaeger,David A.;Clennan,Malgorzata Wegrzyn,Tetrahedron Lett.,28,(1987) N 41,4805-4808
    标题:Jaeger,David A.;Clennan,Malgorzata Wegrzyn,Tetrahedron Lett.,28,(1987) N 41,4805-4808

    海关参考信息

    专利信息


    专利号:US-6828466-B2
    优先权日:2002-07-19
    标题:Process for the synthesis of phenols from arenes
    发明人:MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
    权利人:UNIV MICHIGAN STATE
    摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

    专利号:US-10995078-B2
    优先权日:2013-03-13
    标 题:Compounds and compositions for inhibition of FASN
    发明人:BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
    权利人:FORMA THERAPEUTICS INC
    摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

    专利号:US-12336981-B2
    优先权日:2010-09-03
    标题 :Compounds and compositions for the inhibition of NAMPT
    发明人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
    权利人:VALO HEALTH INC; GENENTECH INC
    摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

    专利号:US-9676721-B2
    优先权日:2010-09-03
    标题 :Compounds and compositions for the inhibition of NAMPT
    发明人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
    权利人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
    摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.

    专利号:US-9555039-B2
    优先权日:2011-05-09
    标题:Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT)
    发明人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
    权利人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
    摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)

    专利号:US-2004030197-A1
    优先权日:2002-07-19
    标 题 :Process for the synthesis of phenols from arenes
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    主要参考文献

    [参考文献]: R M Callejon, Et Al. Analysis For Chloroanisoles And Chlorophenols In Cork By Stir Bar Sorptive Extraction And Gas Chromatography-Mass Spectrometry. Talanta. 2007 Mar 30;71(5):2092-7.

    合成参考文献


    摘要:Shi, L., Science of Synthesis: Knowledge Updates, (2024) 1, 22.
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