CAS: 18422-05-4; ((2R,3S,4R,5R)-5-(6-Amino-9H-Purin-9-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methyl Dihydrogen Phosphate Hydrate

该化合物是一种核酸衍生物,广泛用于生化和制药研究,该化合物是细胞能源新陈代谢和信号传导途径的关键中间体,其单氢酸盐形式确保水溶液的稳定性和溶解性,使其适合用于酶研究,细胞培养应用和核酸合成.AMP.H2O的特点是高纯度和一贯性能,符合严格的研究和工业标准.作为ATP和其他核素的前体,它在研究依赖能源的工艺方面发挥着关键作用,使该工艺对学术和商业实验室都具有价值.在受控条件下的适当储存保持其完整性,供长期使用.

英文名称((2R,3S,4R,5R)-5-(6-Amino-9H-Purin-9-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methyl Dihydrogen Phosphate Hydrate
中文名称腺苷-5'-磷酸
IUPAC名称((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate hydrate
其它别名9-(5-O-Phosphonopentofuranosyl)-9H-Purin-6-Amine--Water (1/1); ((2R,3S,4R,5R)-5-(6-Amino-9H-Purin-9-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methyl Dihydrogen Phosphate Hydrate
CAS编号18422-05-4
MFCD编号:MFCD00005750
EINECS号:200-500-0
分子式:C10H16N5O8P
分子量:365.24
产品CID: 944914
产品分类Inhibitors/Agonists → Anti-infection → HSV | Inhibitors/Agonists → PI3K/Akt/mTOR → AMPK | Inhibitors/Agonists → GPCR/G Protein → Adenosine Receptor | Purines | Chemistry → Chemical Biology → Glycoscience | Tetrahydrofurans

相似结构搜索
InChIKey: ZOEFQKVADUBYKV-MCDZGGTQSA-N
InChI=1S/C10H14N5O7P.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,…
计算化学: 氢键受体数11.0氢键供体数5.0可旋转键数4.0

物理性质

熔点183-188 °C (分解)(文献)
沸点798.5 °C at 760mmHg
闪点436.7 °C
密度0.85
PH:-48 º (c=2% in 2% NaOH)
PSA:205.11
LogP:-3.5
旋光度-48º(C=2IN2NAOH)
蒸汽压6.7E-27mmHg at 25°C
溶解性水: With Addition Of Mild Alkalisoluble
敏感性常温常压下稳定避免的物料：氧化物
外观形态白色至类白色固体
储存条件-20°C
产品应用该化合物用于合成亚代氨基苯-5-磷酰胺氨基氨基酯的试剂,作为合成将NMN转化为NAD+的内生NMAN代环丁基转移酶(NMT)活性抑制剂的聚合反应中磷氧素B的活化剂.

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
UN编号NONH for all modes of transport
危险品标志Xi
安全声明26-36
危险类别码36/37/38
WGK Germany3

合成工艺路线路线简述

海关参考信息

2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-9201673-A1
优先权日:1990-07-17
标题 :Synthesis and uses of spin labelled ribonucleosides and ribonucleotides
发明人：TRENTHAM DAVID ROSTRON; CORRIE JOHN EDGAR THOMAS; ALESSI DARIO RENATO; TRAYER IAN PATRICK
权利人:MEDICAL RES COUNCIL
摘要:Compounds of formulae (1), wherein R represents a CH3 or CD3 group; R<1> represents an alkyl group; R<2> represents an alkyl or aryl group; and N may be either an <14>N or <15>N atom, with the proviso that when R represents CD3, the methylene and vinyl hydrogen atoms of the six-membered ring are deuterium; and (2), wherein R and N are as defined above, X represents hydrogen or a mono-, di- or triphosphate group, or a phosphate ester derivative; and Y represents a purine or pyrimidine base, with the proviso that when R represents CD3, the methylene hydrogen atoms of the six-membered piperidine ring are hydrogen or deuterium. Processes for the preparation of these compounds are also described. The spin labelled nucleotide and nucleoside compounds are suitable for use as probes, for example, in protein structure and orientation studies.

专利号:CN-118290506-A
优先权日:2024-01-06
标题 :A method for rApp modification of oligonucleotides based on solid phase synthesis