CAS: 1791-73-7; 6-Methyl-2,4-Pyrimidinediamine

相似化合物

500158-32-7 514854-12-7 3435-28-7

上下游产品

CAS号5600-21-5 2-氨基-4-氯-6-甲基嘧啶 | CAS号50-01-1 盐酸胍 | CAS号70807-22-6 cyanoacetone so... | CAS号5424-21-5 2,4-二氯-6-甲基嘧啶 | CAS号3438-46-8 4-甲基嘧啶 | CAS号1118-61-2 3-氨基巴豆腈 | CAS号7664-41-7 氨 | CAS号189810-94-4 2,4-Diamino-5-I... | CAS号2829-59-6 6-甲基-5-硝基-2,4-吡啶二胺 | CAS号6344-09-8 N-(4-acetamido-...

📜2,4-二氯-6-甲基嘧啶置于氨体系中,化学反应生成6-甲基-2,4-嘧啶二胺
参考文献:Gabriel; Colman,Chemische Berichte,1901,Vol. 34,P. 1242
标题:Gabriel; Colman,Chemische Berichte,1901,Vol. 34,P. 1242

专利信息

专利号:US-5874433-A
优先权日:1993-11-29
标题 :Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
发明人：GROSS STEVEN S
权利人:CORNELL RES FOUNDATION INC
摘要:Inhibitor of the use of tetrahydrobiopterin as a cofactor for nitric oxide synthase, e.g., substituted 4-phenyl(hydropyridines) such as 1-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine or, 4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine) or tetrahydropterin analog which does not replace tetrahydrobiopterin as a substrate for nitric oxide synthase such as (6R,S)-6,7-dimethyl-tetrahydropterin or (6R,S)-tetrahydrofolic acid or 2,4-diamino-, 2,6-diamino, or 4,6-diamino mono- or disubstituted pyrimidines or the corresponding pyrimidine-3-oxides such as 2,4-diamino-6-(diethylamino)pyrimidine, 2,4-diamino-6-piperidino-pyrimidine-3-oxide, 2,4-diamino-6-hydroxypyrimidine, 4,6-diamino-2-hydroxypyrimidine or 2,5-diamino-4,6-dihydroxypyrimidine is administered to inhibit nitric oxide synthesis from arginine in vascular cells in a subject in need of such inhibition (e.g., for prophylaxis or treatment of cytokine- or endotoxin-induced hypotension (e.g., septic shock). The latter two types are advantageously administered with nitric oxide synthase inhibitors (concurrent therapy) or to potentiate the effect of α 1 -adrenergic agonists in the prophylaxis or treatment of induced hypotension.

专利号:WO-2021078995-A1
优先权日:2019-10-25
标 题 :Selective polypeptide synthesis stalling assay and compound
发明人：STROUS GERARDUS JACOBUS ANTONIUS MARIA; MOL JAN ADRIANUS; VAN DER VELDEN LIEKE MARIE; KLUMPERMAN JUDITH; MAAS PETRUS EMMANUEL MARIE; PIET DENNIS PATRICK; DE KLERK-SPRENKELS NANDA ELISABETH; TIJHUIS JOHANN HEINRICH; VIÉTOR HENDRIK ENGELBERTUS; MAURICE MADELON MARIA; VAN DER KRIFT FELIX
权利人:UMC UTRECHT HOLDING BV; UNIV UTRECHT HOLDING BV; BIMINI BIOTECH B V
摘要:The invention relates to compounds, in particular pyrimidine-2,4-diamines, analogues and salts thereof and pharmaceutical compositions comprising pyrimidine-2,4-diamines analogues and salts thereof for use in the treatment and prevention of a disease, in particular a growth hormone receptor-dependent condition. The invention also relates to methods of using these compounds and compositions to treat physiological disorders related to the amount or activity of growth hormone. In a particular embodiment, the invention relates to a compound according to formula 1 for use in the treatment or prevention of a disease in a subject.

专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人：WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

专利号:WO-9514468-A1
优先权日:1993-11-29
标题:Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis

专利号:EP-0730451-A4
优先权日:1993-11-29
标题 :INHIBITION OF THE USE OF TETRAHYDROBIOPTERIN TO BLOCK THE INDUCTION OF NITRIC OXIDE SYNTHESIS

专利号:EP-0730451-A1
优先权日:1993-11-29
标题 :Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis