CAS: 175968-39-5; 2,3-Difluoro-4-Hydroxybenzoic Acid

上下游产品

4-(苄氧基)-2,3-二氟苯甲酸 4-(Benzyloxy)-2,3-Difluorobenzoic Acid 144292-54-6
2,3-Difluoro-4-((Triisopropylsilyl)Oxy)Benzoic Acid 1010800-88-0
2,3,4-三氟苯甲酸 2,3,4,-Trifluorobenzoic Acid 61079-72-9
2,3-二氟-4-氰基苯酚 2,3-Difluoro-4-Hydroxybenzonitrile 126162-38-7

2,3-二氟苯酚置于2,2,6,6-四甲基哌啶,咪唑,正丁基锂,四丁基氟化铵体系中,用 四氢呋喃,正己烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,反应生成2,3-二氟-4-羟基苯甲酸
参考文献:通过有机金属中间体对二氟苯酚和三氟苯酚进行区域功能化
标题:通过有机金属中间体对二氟苯酚和三氟苯酚进行区域功能化
摘要:2,4-二氟苯酚,2,5-二氟苯酚,2,3-二氟苯酚,3,5-二氟苯酚,3,4-二氟苯酚,2,4,5-三氟苯酚和2,3,4-三氟苯酚全部转化为18可能的二氟化或三氟化羟基苯甲酸,它们都是新化合物.酚氢原子被甲氧基甲基或不太常见的三异丙基甲硅烷基取代,其分别发挥邻位活化或邻位屏蔽作用.两侧有两个电子管的站点.取代基(氟,烷氧基)特别容易去质子化.如果要在其他地方引入金属,它们必须通过金属化阻断三甲基甲硅烷基或金属化偏转氯原子的可逆连接来沉默.在所有情况下,除了一个,因此为intramol设置了舞台.邻氧或邻氟位点的金属化之间的竞争.通过依赖适当的底物-试剂匹配,确实可以以任何一种方式确保所需的区域灵活性.这再次证明了有机金属方法在面向多样性的合成中的潜力.[关于 Scifinder (R)]
Doi:10.1055/s-2004-829110

专利信息

专利号:US-2009264648-A1
优先权日:2008-01-14
标题:Synthesis of pyrazoles
发明人：CHEW WARREN; WANG ZHENG; CHEAL GLORIA; BERTRAND MARTIAL; POTOSKI JOHN; MIRMEHRABI MAHMOUD; NENCINI ARIANNA; ZANALETTI RICCARDO
权利人:WYETH CORP; SIENA BIOTECH SPA
摘要:The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.

专利号:WO-2009091832-A1
优先权日:2008-01-14
标题 :Synthesis of pyrazoles

专利号:US-6613942-B1
优先权日:1997-07-01
标题 :Glucagon antagonists/inverse agonists
发明人：LING ANTHONY; GREGOR VLAD; GONZALEZ JAVIER; HONG YUFENG; KIEL DAN; KUKI ATSUO; SHI SHENGHUA; NAERUM LARS; MADSEN PETER; SAMS CHRISTIAN; LAU JESPER; PLEWE MICHAEL BRUNO; FENG JUN; TENG MIN; JOHNSON MICHAEL DAVID; TESTON KIMBERLY ANN; SIDELMANN ULLA GROVE; KNUDSEN LOTTE BJERRE
权利人:NOVO NORDISK AS
摘要:Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.