CAS: 162626-99-5; 3-(4-Ethyl-2-Hydroxyimino-5-Nitrohex-3-Enyl)Pyridine-2-Carboxamide

上下游产品

(E)-2-ethyl-2-butenal ethyl (E,E)-4-ethylhexa-2,4-dienoate (E,E)-4-ethylhexa-2,4-diene-1-ol (E,E)-1-acetoxy-4-ethyl-2,4-hexadiene

📜2-乙基-丁-2-烯醛置于吡啶,盐酸,Lithium Aluminium Tetrahydride,四(三苯基膦)钯,Sodium Hydride,肼,Sodium Nitrite体系中,用 四氢呋喃,乙醇,水,N,N-二甲基甲酰胺 用作溶剂,化学反应生成(+/-)-{(E)-4-乙基-2-[(Z)-羟亚氨基]-5-硝基-3-己烯基-1-基}-吡啶甲酰胺
参考文献:New Reagents For Controlled Release Of Nitric Oxide. Structure-Stability Relationships
标题:New Reagents For Controlled Release Of Nitric Oxide. Structure-Stability Relationships
摘要:The Synthesis And Structure-Stability Relationships Of A Series Of Novel Fk409 Derivatives (1,2,And 3) Are Described. The Rates Of Decomposition In Aqueous Solution (Ph 8.0,30 Degrees C) Were Parallel With Those Of Spontaneous No Release Measured By Esr Spectroscopy Using Carboxy-Ptio. The Compounds Can Cover A Wide Range Of No Releasing Rates By Appropriate Modification Of The Molecule.
Doi:10.1016/0960-894X(95)00547-7

专利信息

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.