CAS: 16051-77-7; Isosorbide Mononitrate

上下游产品

CAS号39813-48-4 ISMN acetate | CAS号87-33-2 硝酸异山梨酯 | CAS号56-23-5 四氯化碳 | CAS号75648-24-7 isosorbide-2-be... | CAS号7664-93-9 硫酸 | CAS号79-31-2 异丁酸 | CAS号652-67-5 异山梨醇 | CAS号13042-39-2 异山梨醇-2-醋酸酯 | CAS号13042-38-1 (3R,3aR,6S,6aR)... | CAS号84207-83-0 isosorbide 2-O-...

硝酸异山梨酯置于二异丙氧基二氯化钛,Benzyltriethylammonium Borohydride体系中,用 二氯甲烷 用作溶剂,化学反应 2.0H,以57%的收率获得5-单硝酸异山梨酯
参考文献:Highly Chemoselective Reduction Of 2,5-Dinitro-1,4:3,6-Dianhydro-D-Glucitol With Titanium(III) Tetrahydroborates: Efficient Synthesis Of Isomerically Pure 2-And 5-Nitro-1,4:3,6-Dianhydro-D-Glucitols
标题:Highly Chemoselective Reduction Of 2,5-Dinitro-1,4:3,6-Dianhydro-D-Glucitol With Titanium(III) Tetrahydroborates: Efficient Synthesis Of Isomerically Pure 2-And 5-Nitro-1,4:3,6-Dianhydro-D-Glucitols
摘要:研究发现,2,5-二硝基-1,4:3,6-二氢-D-葡萄糖醇(1)被四氢硼酸钛(III)(2)(-78-> 0oc)还原后,只能得到 2-硝基-1,4:3,6-二氢-D-葡萄糖醇(3).另一方面,用二异丙氧基钛(III)四氢硼酸酯(4)(-78-> 0oc)还原二硝酸酯 1,得到的唯一产物是 5-硝基-1,4:3,6-二氢-D-葡萄糖醇(5).
Doi:10.1055/s-1994-25631

专利信息

专利号:WO-2015036637-A1
优先权日:2013-09-13
标题:Method for the synthesis of kojibiose and the application thereof in the production of food and pharmaceutical compositions
发明人：DIEZ MUNICIO MARINA; MORENO ANDUJAR FRANCISCO JAVIER; HERRERO CALLEJA MIGUEL; MONTILLA CORREDERA ANTONIA
权利人:CONSEJO SUPERIOR INVESTIGACION
摘要:The invention relates to a method for the synthesis of kojibiose, characterised by its simplicity and high yield, using a starting reaction mixture containing, as the main compound thereof, the trisaccharide 2-α-D-glucopyranosyl-lactose, O-β-D-galactopyranosyl-(1→4)-O-[α-D-glucopyranosyl- (1→2)]-β-D-glucopyranose, and leucrose, lactose, fructose, glucose and saccharose, said method comprising steps of fermentation, hydrolysis and purification, allowing the production of a disaccharide with high added value, such as kojibiose, in a cost-effective manner. The invention also relates to the kojibiose produced by means of the method according to the invention, and to the use of same in the production of prebiotic food compositions in order to prevent pathologies relating to the gastrointestinal system, and pharmaceutical compositions for treating viral-type diseases or for delaying the digestion of carbohydrates.

专利号:US-4381400-A
优先权日:1981-02-27
标 题 :Process for the synthesis of isosorbide mononitrates
发明人：EMEURY JEAN-MARIE; WIMMER ERIC
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The invention relates to the synthesis of isosorbide mononitrates. n The process according to the invention consists in reacting a hydrazine derivative with isosorbide dinitrate, in a polar solvent medium. The reaction is preferably carried out at the reflux temperature of the solvent medium, with an excess of the hydrazine derivative. A preferred solvent medium is a mixture of tetrahydrofuran and methanol. The process leads to the preferential formation of isosorbitol-2-mononitrate, which is a coronary vasodilator.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:WO-2022193577-A1
优先权日:2021-03-15
标题 :Synthesis method for isosorbide mononitrate and application thereof
发明人：XIAO HANWEN; FU YONGHONG; LIN FANGYU; Zheng Yuannv; LIN XIAOXUE; Tang Xiongzhao
权利人:CHINA MEHECO KANGLI PHARMA CO LTD
摘要:The present invention belongs to the field of pharmaceutical synthesis, and disclosed are a synthesis method for isosorbide mononitrate and the application thereof. The synthesis method for isosorbide mononitrate provided by the present invention involves using a one-pot method and comprises taking sorbitol, and adding the sorbitol to concentrated sulfuric acid; and after dehydration and ring closing, adding a nitrate to perform a nitration reaction, and then adding zinc powder to perform a reduction reaction to then obtain isosorbide mononitrate. The synthesis method has a simple process flow and high raw material utilization, and saves on production costs. The present invention is suitable for the synthesis of isosorbide mononitrate, and the obtained isosorbide mononitrate is used for the preparation of isosorbide mononitrate for injection.

专利号:US-2024222113-A1
优先权日:2022-12-29
标 题:Passivation of crystalline substrate for metal chalcogen material synthesis
发明人：NAYLOR CARL H; MAXEY KIRBY; OBRIEN KEVIN; DOROW CHELSEY; LEE SUDARAT; PENUMATCHA ASHISH VERMA; AVCI UYGAR; METZ MATTHEW; CLENDENNING SCOTT B; KAVRIK MAHMUT SAMI; LIN CHIA-CHING; KITAMURA Ande
权利人:INTEL CORP
摘要:Integrated circuit (IC) structures comprising transistors with metal chalcogenide channel material synthesized on a workpiece comprising a Group IV crystal. Prior to synthesis of the metal chalcogenide material, a passivation material is formed over the Group IV crystal to limit exposure of the substrate to the growth precursor gas(es) and thereby reduce a quantity of chalcogen species subsequently degassed from the workpiece. The passivation material may be applied to the front side, back side, and/or edge of a workpiece. The passivation material may be sacrificial or retained as a permanent feature of an IC structure. The passivation material may be advantageously amorphous and/or a compound comprising at least one of a metal or nitrogen that is good diffusion barrier and thermally stable at the metal chalcogenide synthesis temperatures.

专利号:US-2012178129-A1
优先权日:2009-05-11
标 题 :Gene synthesis method
发明人：LI MO HUANG; YANG JACKIE Y; WAI CHYE CHEONG; BODE MARCUS
权利人:LI MO HUANG; YANG JACKIE Y; WAI CHYE CHEONG; BODE MARCUS
摘要:The present invention relates to polymerase chain reaction (PCR)-based methods for the one-step synthesis of nucleic acid molecules, wherein the amplification primers used in said methods are designed such that they have two distinct melting temperatures in order to minimize the competition between polymerase cycling assembly (PCA) and polymerase chain reaction (PCR) amplification in the one-step nucleic acid synthesis and to maximize the emerging full-length amplification, as well as kits for use in such methods.