CAS: 149908-53-2; 1-(((5-(4-Chlorophenyl)Furan-2-yl)Methylene)Amino)-3-(4-(4-Methylpiperazin-1-yl)Butyl)Imidazolidine-2,4-Dione

Azimilide置于碳酸氢钠体系中,用 水 用作溶剂,化学反应生成阿齐利特
参考文献:4-Oxocyclic Ureas Useful As Antiarrhythmic And Antifibrillatory Agents
标题:4-Oxocyclic Ureas Useful As Antiarrhythmic And Antifibrillatory Agents
摘要:本发明的新型4-氧代环脲及其药用可接受盐和酯可用作抗心律失常和抗颤荡剂,具有以下一般结构:其中(A) X为饱和或不饱和的5,6或7元杂环或碳环;(B) R选自共价键,零,杂原子,羰基,杂环环,碳环,烷基,烯基,烷氧基,烷基氨基,芳基烷基,芳氧基,酰基,酰氧基和酰氨基组成的群体;(C) Y为取代或未取代的饱和或不饱和的5,6或7元杂环环或碳环,或为零;当r为零时,X和y为融合环系统;当r为共价键时,X和y通过共价键连接为环系统;当y为零时,R为共价键,X通过r与l相结合;(D) R1,R2和r3分别选自零,Cl,F,Br,Nh2,Cf3,Oh,So3H,Ch3So2Nh,Cooh,烷氧基,烷基,烷氧羰基,羟基烷基,羧基烷基,氨基烷基,酰胺基和酰氧基组成的群体;(E) L选自烷基氨基,烯基氨基,烷基亚胺,烯基亚胺和酰胺基;其中其氮原子与4-氧代环脲基团1-位置的氮原子结合;(F) R4选自烷基,烯基,炔基,烷基酰和杂烷基的群体;(G) A为取代或未取代的饱和或不饱和的直链或支链c1-C8杂烷基;或取代或未取代的饱和或不饱和的5,6或7元杂环,A具有一个氮原子,与r4相邻;(H) R5为取代或未取代的c1或c2烷基.

专利信息

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-10308615-B2
优先权日:2015-05-29
标 题:Heterocyclic compounds as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; CONDON JEFFREY SCOTT; FLICK ANDREW CHRISTOPHER; GOPALSAMY ARIAMALA; KIRINCICH STEVEN J; MATHIAS JOHN PAUL; STROBACH JOSEPH WALTER; XIANG JASON SHAOYUN; XING LI HUANG; WANG XIAOLUN
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:RU-2194706-C2
优先权日:1998-04-29
标题 :Method of synthesis of 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]- 3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride

专利号:US-6413785-B1
优先权日:1998-02-20
标题:Solid phase synthesis of 1-aminohydantoins
发明人：WILSON LAWRENCE JOSEPH; PORTLOCK DAVID EDWARD; LI MIN
权利人:PROCTER & GAMBLE
摘要:The subject invention involves processes for making 1-aminohydantoin compounds using a solid support resin, comprising the following steps; (a) preparing a resin-bound protected α-hydrazinyl ester; (1) by reacting the resin with an α-bromo carboxylic acid, then with a protected hydrazine; or (2) by reacting the resin with a protected α-hydrazinyl carboxylic acid; (b) preparing a resin-bound imine by removing the blocking group from the hydrazinyl moiety, then reacting the unprotected hydrazinyl moiety with an aldehyde or ketone; (c) preparing a resin-bound secondary urea: (1) by reacting the imine with p-nitrophenylchloroformate or trisphosgene, then with a primary amine; or (2) by reacting the imine with an isocyanate, and (d) preparing the 1-aminohydantoin compound by removing the secondary urea from the resin and cyclizing it.

专利号:WO-9942450-A1
优先权日:1998-02-20
标题:Solid phase synthesis of 1-aminohydantoins

专利号:EP-1056726-A1
优先权日:1998-02-20
标题:Solid phase synthesis of 1-aminohydantoins