4-N-丁基氯苯置于硼酸三甲酯体系中,用 N,N-二甲基甲酰胺 用作溶剂,以38%的收率获得4-正丁基苯硼酸 参考文献:Novel Synthesis Of Arylboronic Acids By Electroreduction Of Aromatic Halides In The Presence Of Trialkyl Borates 标题:Novel Synthesis Of Arylboronic Acids By Electroreduction Of Aromatic Halides In The Presence Of Trialkyl Borates 摘要:一种通过电化学偶联反应制备芳基和杂芳基硼酸的新方法被描述.该方法基于芳香或杂芳香卤化物与三烷基硼酸酯之间的还原偶联.反应在单室电池中进行,使用牺牲性铝或镁阳极,溶剂为dmf或thf.得到的芳基硼酸具有中等到非常好的选择性和分离产率. Doi:10.1039/b200744B
专利号:US-12187735-B2 优先权日:2018-09-17 标 题:Matter of composition, synthesis, formulation and application of FL118 platform positions 7 and 9-derived analogues for treatment of human disease 发明人:LING XIANG; LI QINGYONG; LI FENGZHI 权利人:CANGET BIOTEKPHARMA LLC 摘要:Described herein, are the chemical synthesis, matter of compositions, formulation, function, methods and uses of the FL118 platform Positions 7 and/or 9-derived analogues for treating cancer or other human diseases. Compounds derived from chemical modifications of the FL118 platform are employed alone or in combination with other anti-cancer agents to preclude, eliminate or reverse cancer phenotypes. This invention intends to realize unique personalized cancer treatment (personalized precision medicine) through application of a series of structural relevant individual FL118 platform-derived analogues, which target multiple cellular human disease-relevant proteins and their signaling pathways.
专利号:US-2025092058-A1 优先权日:2018-09-17 标 题 :Matter of composition, synthesis, formulation and application of fl 118 platform positions 7 and 9-derived analogues for treatment of human disease 发明人:LING XIANG; LI QINGYONG; LI FENGZHI 权利人:CANGET BIOTEKPHARMA LLC 摘要:Described herein, are the chemical synthesis, compounds, methods and uses of the fluoroaryl-substituted derivatives at the FL118 position 7, which target multiple cellular human disease-relevant proteins and their signaling pathways.
专利号:US-11767302-B2 优先权日:2020-10-01 标题 :Reagents and methods for tetrazine synthesis 发明人:FOX JOSEPH M; LAMBERT WILLIAM; FANG YINZHI; AM ENDE CHRISTOPHER WILLIAM; MAHAPATRA SUBHAM; XIE YIXIN; WANG CHUANQI 权利人:UNIV DELAWARE 摘要:Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.
专利号:WO-2020061106-A2 优先权日:2018-09-17 标 题 :Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease
专利号:CA-3111403-A1 优先权日:2018-09-17 标 题:Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease
专利号:EP-3852760-A2 优先权日:2018-09-17 标题 :Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease