专利号:US-8383810-B2 优先权日:2004-12-20 标题:Process for the synthesis of azetidinones 发明人:THIRUVENGADAM TIRUVETTIPURAM K; CHIU JOHN S; FU XIAOYONG; MCALLISTER TIMOTHY L 权利人:MERCK SHARP & DOHME; THIRUVENGADAM TIRUVETTIPURAM K; CHIU JOHN S; FU XIAOYONG; MCALLISTER TIMOTHY L 摘要:A process is provided for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, comprising reacting a β-(substituted-amino)amide, a β-(substituted-amino)acid ester, or a β-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride, wherein a quaternary ammonium moiety of the cyclizing agent is unsubstituted or substituted by one to four groups independently selected from the group consisting of alkyl, arylalkyl and arylalkyl-alkyl.
专利号:WO-2004074215-A1 优先权日:2003-02-03 标 题 :Process for preparation of clopidogrel, its salts and pharmaceutical compositions 发明人:NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI 权利人:NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI 摘要:The invention discloses an improved process for racemization of methyl (R)Â(-) alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate , a stereoisomer formed in the synthesis of clopidogrel i.e. methyl (S)-(+)-alpha (2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate or its salts. The invention is also for an improved process for production of clopidogrel or its pharmaceutically acceptable salts. The invention further discloses novel clopidogrel salts and pharmaceutical compositions comprising them.
专利号:US-4683299-A 优先权日:1984-08-10 标 题:Sugar esters and an improved anhydrous method of manufacture 发明人:KEA SANDRA; WALKER CHARLES E; KLINE ERIC 权利人:NEBRASKA STATE 摘要:The invention relates to an improved process for the synthesis of sugar esters carried out in a substantially anhydrous system and in the presence of an organic acid chloride. Any of the known available sugars may be used and in particular hydrolyzate sugars derived from starch are effectively employed in accordance with the present invention to produce sugar esters having superior emulsifying characteristics for use as an ingredient in food products for human consumption.
专利号:US-2006078560-A1 优先权日:2003-06-23 标 题 :Method of inducing apoptosis and inhibiting cardiolipin synthesis 发明人:JAMIL HARIS; AHMAD MOGHIS U; AHMAD IMRAN 权利人:NEOPHARM INC 摘要:The present invention provides a method for inducing apoptosis within a cell by exposing the cell to an inhibitor of cardiolipin synthesis under conditions sufficient to induce apoptosis within the cell. The method can be used to investigate or treat disorders such as cancer, obesity, and cardiovascular disorders. The invention also provides a pharmaceutical composition including an inhibitor of cardiolipin synthesis and a liposomal carrier.
专利号:US-6716437-B1 优先权日:1993-09-13 标 题:Topical composition and method for enhancing lipid barrier synthesis 发明人:PELLE EDWARD; ANDERSON JON 权利人:E L MANAGEMENT CORP 摘要:The present invention relates to topical compositions useful in enhancing lipid synthesis in skin comprising an effective amount of cafestol or kahweol, or derivative thereof, in combination with a pharmaceutically or cosmetically acceptable carrier. Such compositions are useful in treatment or prevention of dry skin and conditions in which the skin's lipid barrier is defective or damaged.
专利号:US-2024067875-A1 优先权日:2022-08-24 标 题 :Process for synthesis of b-site doped abx3 perovskite nanocrystals
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