CAS: 140631-53-4; 4-(3,4-Dichlorophenyl)-N-Methyl-1,2,3,4-Tetrahydronaphthalen-1-Amine

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329009-20-3 79617-89-3 79836-45-6

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CAS号593-51-1 一甲胺盐酸盐 | CAS号79560-19-3 4-(3,4-二氯苯基)-1-四氢萘酮 | CAS号101-02-0 亚磷酸三苯酯 | CAS号79560-20-6 萘亚胺 | CAS号123-39-7 N-甲基甲酰胺 | CAS号79617-89-3 4-(3,4-二氯苯基)-1,...

专利信息

专利号:US-2001044142-A1
优先权日:2000-04-28
标题:Microbial reductase useful for the stereoselective reduction of a racemic tetralone
发明人：BROWN MARIA S; FEDECHKO RONALD W; WONG JOHN W
摘要:The present invention relates to novel compositions of matter comprising an enzyme activity capable of carrying out the following stereoselective reduction of a racemic tetralone: n n n The chiral tetralone can be used in the synthesis of sertraline, well known to be useful, for example, as an antidepressant and anorectic agent, and in the treatment of chemical dependencies, anxiety-related disorders, premature ejaculation, cancer and post-myocardial infarction.

专利号:WO-2020025646-A1
优先权日:2018-07-30
标题:An omega-transaminase enzyme
发明人：MAGUIRE ANITA; GAVIN DECLAN; O'GARA FERGAL; REEN JERRY
权利人:UNIV COLLEGE CORK NATIONAL UNIV OF IRELAND CORK
摘要:An isolated w-transaminase enzyme comprising an amino acid sequence of SEQUENCE ID NO: 1, or encoded by a nucleic acid sequence of SEQUENCE ID NO: 2, is provided which is derived from marine sponge Pseudovibrio sp.. Also provided are functional variants of the w-transaminase enzyme that are isolated, have at least 80% sequence identity with SEQUENCE ID NO: 1, and are capable of enantioselectively resolving a racemic amine by transformation to a ketone by oxidative deamination, or enantioselectively resolving a racemic ketone by transformation to an amine by reductive amination, in which the amine and ketone typically contain a stereocentre removed from the reacting site. An example of a functional variant is SEQUENCE ID NO:3. In one embodiment, the functional variant is capable of enantioselectively transforming a (4S) -tetralone intermediate in the synthesis of sertraline, in which the functional variant displays remote stereospecificity for the tetralone intermediate.

专利号:US-6589777-B1
优先权日:1998-10-29
标题:Stereoselective microbial reduction of a racemic tetralone
发明人：MORSE BROOK K; TRUESDELL SUSAN J; WONG JOHN W
权利人:PFIZER
摘要:The present invention relates to processes for carrying out the following stereoselective microbial reduction of a racemic tetralone: n which comprises: contacting a compound of formula (I) with a microorganism, or an enzyme reduction system capable of accomplishing the subject reduction comprising an enzyme derived from said microorganism and a co-factor for said enzyme, and incubating the resulting mixture under conditions sufficient to yield the (4R) tetralol of formula (II) and to leave substantially unreacted the (4S) tetralone of formula (V) or “chiral tetralone.â€? The chiral tetralone can be used in the synthesis of sertraline. The subject process further optionally comprises the separation of the (4S) tetralone of formula (V) from the (4R) tetralol of formula (II). The (4R) tetralol can be recycled to produce the compound of formula (I) and the subject process repeated to result in even more of the desired (4S) tetralone of formula (V).

专利号:US-7385064-B1
优先权日:2005-11-30
标题 :Catalysts for use in enantioselective synthesis
发明人：DAVIES HUW M L; REDDY RAVISEKHARA P
权利人:UNIV NEW YORK STATE RES FOUND
摘要:Disclosed are compounds having the following formula: n nin which Z 11 is selected from a substituted or unsubstituted saturated adamantyl or other polycyclic group and a substituted or unsubstituted branched acyclic group containing at least 5 carbon atoms at least one of which is a tertiary carbon; and in which Z 12 is a cyclic imide. Methods of using these compounds as chiral catalysts for carbenoid reactions and for enantioselective C—H aminations are also described.

专利号:US-2007260090-A1
优先权日:2005-06-03
标 题:Highly Steroselective Synthesis of Sertraline

专利号:WO-0130742-A1
优先权日:1998-11-23
标题:Improved synthesis of racemic sertraline