CAS: 136552-06-2; (S)-1-(((9H-Fluoren-9-yl)Methoxy)Carbonyl)Azetidine-2-Carboxylic Acid

该化合物是一种受保护的丙丁二-carboxylic酸衍生物,其特点是氮基位置的Fmoc(9-氟烯基甲基丙基)组,该组在peptide合成中特别有用,该组作为保护地雷的动物,在温和的基本条件下能够有选择地减少保护.该组的立体特性(2S)确保与手工业合成应用相兼容.其硬性丙酸环结构有助于在peptide设计中造成符合性限制,影响二级结构形成.碳箱酸功能允许通过标准恐吓规程进一步衍生或组合.由于稳态丙胺合成(SPPS)和药用化学研究的稳定性和矫形保护策略,该试剂通常用于固基聚物合成和药用化学研究.

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相似化合物

374791-02-3 184763-07-3 2133-34-8

物理性质

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ECHA物质C&L通报

上下游产品

CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号2133-34-8 (|S|)-(-)-2-羧基环丁胺 | CAS号497-19-8 纯碱

合成工艺路线路线简述

    📜氯甲酸-9-芴基甲酯,(S)-(-)-2-羧基环丁胺 以 1,4-二氧六环,Sodium Carbonate 用作溶剂,化学反应生成1-氯甲酸芴甲酯-(S)-吖丁啶-2-羧酸
    参考文献:Anti-Thrombotic Peptide And Pseudopeptide Derivatives
    标题:Anti-Thrombotic Peptide And Pseudopeptide Derivatives
    摘要:本文披露了新型肽和伪肽衍生物以及它们的药物组合物,可抑制哺乳动物血液中的血小板聚集和血栓形成.

    海关参考信息

    专利信息


    专利号:US-2023220001-A1
    优先权日:2020-06-09
    标 题:Method for synthesis of thioether-containing peptides
    发明人：GRUSS HENDRIK; LUTZ CHRISTIAN; SÃœSSMUTH RODERICH; Yao guiyang; KNITTEL CAROLINE; KOSOL SIMONE; MAINZ ANDI
    权利人:HEIDELBERG PHARMA RES GMBH
    摘要:The present invention relates to a method of formation of a sulphur bridge between tryptophan and cysteine in solid phase peptide synthesis under iodine treatment. The invention also relates to the resulting compounds of the method and their respective use.

    专利号:US-2023391818-A1
    优先权日:2020-11-05
    标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
    发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
    权利人:CHUGAI PHARMACEUTICAL CO LTD
    摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.

    专利号:US-8410028-B2
    优先权日:2003-12-17
    标 题:Methods for synthesis of encoded libraries
    发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
    权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
    摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

    专利号:US-2024287106-A1
    优先权日:2021-06-09
    标题 :Method for Producing Fluorescent Probe Library Using Solid-Phase Extraction and Method of Measuring Enzyme Activity Using Same
    发明人：KOMATSU TORU; URANO YASUTERU; SAKAMOTO SHINGO; WATANABE RIKIYA; KAGAMI YU
    权利人:UNIV TOKYO; RIKEN
    摘要:To provide a synthesis scheme capable of easily synthesizing various kinds of fluorescent probes. A method for preparing a compound represented by Formula (III) below, the method including steps (1) to (5).

    专利号:US-2007042401-A1
    优先权日:2003-12-17
    标题 :Methods for synthesis of encoded libraries

    专利号:US-2012245040-A1
    优先权日:2003-12-17
    标题 :Methods for synthesis of encoded libraries

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