CAS: 134002-25-8; (S)-2,2-Diphenyl-2-(Pyrrolidin-3-yl)Acetamide

英文名称(S)-2,2-Diphenyl-2-(Pyrrolidin-3-yl)Acetamide
中文名称3-(S)-(1-氨基甲酰基-1,1-二苯基甲基)吡咯烷
IUPAC名称(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)acetamide
其它别名(S)-Alpha,Alpha-Diphenyl-3-Pyrrollidineacetamide; 3-(S)-(1-Carbamoyl-1,1-Diphenylmethyl)Pyrrolidine; (S)-Alpha,Alphal-Diphenyl-3-Pyrrolidineacetamide-L-Tartrate(Darifenacin); (S)-Alpha,Alphal-Diphenyl-3-Pyrrolidineacetamide; (3S)-Diphenyl-3-Pyrrolidineacetamide; (S),-L,L-Dipenyl-3-Pyrrolidine Acetamide L-Tartaric Acid Salt; 3-(S)-(1-Carbamoyl-1; (S)-3-(1-Carbamoyl-1,1-Diphenylmethyl)Pyrrolidine
CAS编号134002-25-8
MFCD编号:MFCD09263622
FDA UNII编号:60BD005469
分子式:C18H20N2O
分子量:280.37
产品CID: 513592
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: IVJSBKKYHVODFT-MRXNPFEDSA-N
InChI=1S/C18H20N2O/c19-17(21)18(16-11-12-20-13-16,14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10,16,20H,11-13H2,(H2,19,21)/t16-/m1/s1…
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数4.0

相似化合物

194602-27-2 1092540-94-7 134002-26-9

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P280-P302+P352

上下游产品

CAS号133099-11-3 (S)-alpha,alpha... | CAS号1189753-52-3 (S)-2,2-dipheny... | CAS号40499-83-0 3-羟基吡咯烷 | CAS号133099-07-7 氢溴酸达非那新 | CAS号133099-04-4 达非那新

合成工艺路线路线简述

3(S)-(+)-2,2-Diphenyl-2-(Pyrrolidin-3-yl)Acetonitrile Oxalate置于sodium Hydroxide,硫酸,水体系中,化学反应 10.25H,反应生成3-(S)-(1-氨基甲酰-1,1-二苯基甲基)吡咯烷
参考文献: Novel And Improved Processes For The Preparation Of Intermediates Of Darifenacin,Darifenacin And Its Pharmaceutically Acceptable Salts[fr] Procédés Nouveaux Et Perfectionnés Pour La Préparation D'Intermédiaires De Darifénacine,De La Darifénacine Et De Ses Sels Pharmaceutiquement Acceptables
标题: Novel And Improved Processes For The Preparation Of Intermediates Of Darifenacin,Darifenacin And Its Pharmaceutically Acceptable Salts[fr] Procédés Nouveaux Et Perfectionnés Pour La Préparation D'Intermédiaires De Darifénacine,De La Darifénacine Et De Ses Sels Pharmaceutiquement Acceptables

海关参考信息

2902600000-乙苯
2902700000-异丙基苯
2912110000-甲醛
2912120000-乙醛
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专利信息

专利号:WO-2009153649-A1
优先权日:2008-06-19
标题:Process for preparing 3-substituted pyrrolidine compounds
发明人：SOLDEVILLA MADRID NURIA
权利人:MEDICHEM SA; SOLDEVILLA MADRID NURIA
摘要:Disclosed is a process for preparing 3 -substituted pyrrolidine compounds of formula (VII) or salts thereof, wherein R1 is described herein, which are intermediate compounds useful for the synthesis of darifenacin which is indicated for the treatment of overactive bladder with symptoms of urge, urinary incontinence, and the like, and pharmaceutically acceptable salts thereof. Also disclosed is a process for preparing darifenacin and pharmaceutically acceptable salts thereof.