CAS: 134-36-1; Erythromycin A 2'-Propanoate

该化合物是属于大型滑动类的一种抗生素,主要用于抗菌性,其产物是天然产物红血素,由细菌沙迦罗opollyspora 红血球所产,其特点是它能够通过与50S 脊髓炎亚细胞结合来抑制细菌蛋白合成,使其对各种长效和某些长效阴性细菌有效; 异性色素丙烯酸盐通常以其酯成型形式施用,以提高其药用动力特性,包括改进吸收和减少胃肠副作用; 它看起来是白色的对非白晶粉,在有机溶剂中溶解,但水溶解性有限; 化合物经常用于治疗呼吸道感染,皮肤感染和某些性传播疾病; 与其他抗生素一样,它必须使用红色素丙基,以便明智地防止抗生素抗药性.

结构式图片

上下游产品

红霉素 Erythromycin 114-07-8

合成工艺路线路线简述

    📜丙酸酐,红霉素置于丙酮体系中,化学反应生成红霉素丙酸酯
    参考文献:Stephens; Conine,Antibiotics Annual,P. 346,349
    标题:Stephens; Conine,Antibiotics Annual,P. 346,349

    海关参考信息

    专利信息


    专利号:US-9693999-B2
    优先权日:2011-01-26
    标题:Small molecule RNase inhibitors and methods of use
    发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
    权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
    摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

    专利号:WO-2009056955-A1
    优先权日:2007-10-30
    标题 :Amine-bearing phospholipids (abps), their synthesis and use
    发明人:ZUMBUEHL ANDREAS
    权利人:UNIV BASEL; ZUMBUEHL ANDREAS
    摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

    专利号:US-9868747-B2
    优先权日:2014-02-18
    标题:Marinopyrrole derivatives and methods of making and using same
    发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI
    权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD
    摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

    专利号:US-9907753-B2
    优先权日:2010-03-19
    标 题 :Lipid vesicle compositions and methods of use
    发明人:IRVINE DARRELL J; MOON JAEHYUN
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

    专利号:CN-103396466-A
    优先权日:2013-08-02
    标题 :A kind of synthesis method of Etoerythromycin

    专利号:CN-103396466-B
    优先权日:2013-08-02
    标 题:A kind of synthesis method of Etoerythromycin

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Wiegand RG, Chun AH. Serum protein binding of erythromycin and erythromycin 2'-propionate ester. J Pharm Sci. 1972 Mar;61(3):425-8. doi: 10.1002/jps.2600610322.

    合成参考文献


    摘要:Antibiotics Annual., 6(354), 1958/1959
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知