CAS: 12040-44-7; Alcian Blue 8Gx

该化合物是一种合成染料,常用于组织部分中染色酸性诱杀剂和甘蓝的细胞学和细胞学,是一种显示蓝色的染料,可清晰地直观显微镜下的特定细胞成分. 阿尔西蓝对富含硫酸和碳盒化聚沙酸盐的污渍组织特别有效,在对连接组织,软骨和某些肿瘤的研究中具有价值. 染料在水中溶解,可在各种pH条件下使用,通常是在酸性pH条件下使用,以加强其与负电荷分子的结合. 其应用范围超越了菌学上的污渍; 还在涉及聚沙焦酸盐的生化实验和研究中使用. 一般认为,阿西蓝可以安全地用于实验室用途,但应观察标准的安全防范措施以避免接触.

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    1: Li Q, Zhang L, Huang Z, Wang F, Wu Z, Wang Y. [Effects of recombinant human interferon β1a on the chondrogenic differentiation of human bone marrow mesenchymal stem cell]. Sheng Wu Gong Cheng Xue Bao. 2018 Jun 25;34(6):964-972. doi: 10.13345/j.cjb.170443. Chinese. doi: 10.4317/medoral.22291. doi: 10.4103/jcrt.JCRT_1040_16. doi: 10.3760/cma.j.issn.0529-5807.2018.06.010. Chinese. doi: 10.1186/s13018-018-0837-7.
    7: Quach DT, Le HM, Nguyen TS, Hiyama T. The Distribution of Incomplete Gastric Intestinal Metaplasia (GIM) Subtype among Biopsy Sites according to the Updated Sydney System and Its Association with GIM Extension. Gastroenterol Res Pract. 2018 May 8;2018:4938730. doi: 10.1155/2018/4938730. eCollection 2018.
    8: Gao K, Wang S, Wang Q. [Effect of icariin on serum bone turnover markers expressions and histology changes in mouse osteoarthritis model]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Aug 1;31(8):963-969. doi: 10.7507/1002-1892.201703044. Chinese. doi: 10.1159/000489809. Epub 2018 May 11. doi: 10.1159/000481287. Epub 2017 Nov 8.

    合成参考文献


    参考文献:10.1042/bst0080072
    摘要:Hall RL, Miller RJ, Peatfield AC, Richardson PS, Williams I, Lampert I. A colorimetric assay for mucous glycoproteins using Alcian Blue [proceedings]. Biochem Soc Trans. 1980 Feb;8(1):72. doi: 10.1042/bst0080072.
    参考文献:10.1016/0009-8981(96)06318-8
    摘要:Bhavanandan VP, Martin A, Erickson DR. Quantitation of urinary glycosaminoglycans with Alcian blue: evaluation of the interference by Tamm-Horsfall glycoprotein. Clin Chim Acta. 1996 Jul 30;251(2):207–14. doi: 10.1016/0009-8981(96)06318-8.
    参考文献:10.1007/bf02331425
    摘要:Yang D, Kasamo H, Miyauchi M, Tsuyama S, Murata F. Ontogeny of sulphated glycoconjugate-producing cells in the rat fundic gland. Journal of Molecular Histology. 1996 Jan;28(1):33–43. doi: 10.1007/bf02331425.
    参考文献:10.1007/s00418-002-0389-z
    摘要:Iwatsuki H, Ogawa C, Suda M. Vimentin-positive cells in the villus epithelium of the rabbit small intestine. Histochem Cell Biol. 2002 Apr;117(4):363–70. doi: 10.1007/s00418-002-0389-z.
    参考文献:10.1016/j.femsle.2004.04.025|10.1016/s0378-1097(04)00284-8|10.1111/j.1574-6968.2004.tb09576.x
    摘要:Metcalf JS, Barakate A, Codd GA. Inhibition of plant protein synthesis by the cyanobacterial hepatotoxin, cylindrospermopsin. FEMS Microbiol Lett. 2004 Jun 01;235(1):125–9. doi: 10.1016/j.femsle.2004.04.025.
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