CAS: 115-19-5; 2-Methyl-3-Butyn-2-Ol

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CAS号67-64-1 丙酮 | CAS号74-86-2 乙炔 | CAS号39807-00-6 3-(1-ethoxyetho... | CAS号70277-75-7 lithium acetyli... | CAS号78-83-1 异丁醇 | CAS号4301-14-8 乙炔基溴化镁 | CAS号1066-26-8 乙炔化钠,二甲苯溶液 | CAS号1373155-18-0 2-{[(1,1-dimeth... | CAS号75-20-7 电石 | CAS号123-42-2 二丙酮醇 | CAS号10605-66-0 4-甲基-2-丙炔-1,4-二醇 | CAS号110-65-6 2-丁炔-1,4-二醇 | CAS号67-64-1 丙酮 | CAS号104728-33-8 3,3-dimethyl-6,... | CAS号355-37-3 1H-全氟己烷 | CAS号307-59-5 全氟十二烷 | CAS号55756-24-6 1H-全氟-1-辛炔 | CAS号82721-70-8 5,5,6,6,7,7,8,8... | CAS号3353-69-3 1,2-二(甲基二氯硅基)乙烷 | CAS号33577-98-9 4-(3-羟基-3-甲基-1-...

在 三乙烯二胺体系中,用 苯 用作溶剂,化学反应 2.0H,反应生成2-甲基-3-丁炔-2-醇
参考文献:Organoselenium Chemistry. Formation Of Acetylenes And Allenes By Syn Elimination Of Vinyl Selenoxides
标题:Organoselenium Chemistry. Formation Of Acetylenes And Allenes By Syn Elimination Of Vinyl Selenoxides
摘要:
Doi:10.1021/ja00538A072

专利信息

专利号:WO-2009104605-A1
优先权日:2008-02-18
标 题 :Novel intermediate for synthesis of ascofranone having various physiological activities, and novel shortened total synthesis method for ascofranone using the same
发明人：SAIMOTO HIROYUKI; HAGA YASUSHI
权利人:ARIGEN PHARMACEUTICALS INC; SAIMOTO HIROYUKI; HAGA YASUSHI
摘要:In the synthesis of ascofranone, a compound represented by formula (III), (IV), (V) or (VII) or an optical isomer thereof is used as an intermediate for the synthesis. [In the formulae, R 1 and R 2 independently represent a hydrogen atom, a C 1-7 alkyl group, a phenoxyalkyl group having a halogen atom on a carbon atom in a benzene ring therein, or a phenyl group having a C 1-7 alkoxy group or a C 1-7 alkoxycarbonyl group on a carbon atom in a benzene ring therein; and X represents a halogen atom or a group R 5 SO 3 (wherein R 5 represents a C 1-7 alkyl group or a phenyl group having a C 1-7 alkyl group on a carbon atom in a benzene ring therein).] By using the compound, it becomes possible to reduce the number of steps required for the total synthesis of ascofranone to 7 or 8 from 12 which is a number of the steps required for the conventional ascofranone total synthesis processes.

专利号:WO-2018019549-A1
优先权日:2016-07-28
标 题:Dioxolanone intermediate useful in the synthesis of homoharringtonine
发明人：ALLEGRINI PIETRO; CATTANEO CRISTIAN; CICERI DANIELE; GAMBINI ANDREA; PETERLONGO FEDERICO; CERISOLI LUCIA; LOMBARDO MARCO
权利人:INDENA SPA
摘要:The invention discloses 2-((2R,4R)-4-(4-(benzyloxy)-4-methylpent-2-yn-1-yl)-2-(tert-butyl)-5-oxo-1,3-dioxolan-4-yl)acetic acid of formula (XIX), a process for its preparation and processes for its conversion into enantiomerically pure (R)-2-(2-methoxy-2-oxoethyl)-6,6-dimethyltetrahydro-2H-pyran-2-carboxylic acid of formula (I), a molecule useful for the synthesis of Homoharringtonine.

专利号:US-12037623-B2
优先权日:2018-07-09
标 题 :Enzymatic synthesis of 4′-ethynyl nucleoside analogs
发明人：HUFFMAN MARK A; FRYSZKOWSKA ANNA; KOLEV JOSHUA N; DEVINE PAUL N; CAMPOS KEVIN R; TRUPPO MATTHEW; NAWRAT CHRISTOPHER C
权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME LLC
摘要:The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.

专利号:US-4310467-A
优先权日:1980-10-22
标题:Process and intermediates for the synthesis of vitamin D3 metabolites
发明人：BATCHO ANDREW D; BERGER JR DONALD E; USKOKOVIC MILAN R
权利人:HOFFMANN LA ROCHE
摘要:The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D 3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 20-position. These novel intermediates are prepared from 17-keto steroids by reaction with ethyltriphenylphosphonium halides followed by reaction with formaldehyde to form comounds having the natural steroid configuration at the 20-position and which are suitable substrates for the preparation of the aforementioned Vitamin D 3 metabolites.

专利号:US-4056573-A
优先权日:1975-04-24
标题:Synthesis of acyclic, terpene alcohols
发明人：CLOSE RALPH E; DERFER JOHN M
权利人:SCM CORP
摘要:Shown is a process for the synthesis of acyclic, terpene alcohols, such as 3,7-dimethyloctan-1-o1 and 7-substituted hydroxy or ethoxy derivatives thereof, wherein 3-methylbut-1-yn or the 3-substituted hydroxy or ether derivative thereof is coupled with a C5 coupling reagent having the configuration X being a leaving group such as chloride, bromide, iodide, tosylate and mesylate; R being or OR', R' being a lower alkyl up to 5 carbon atoms, phenyl, substituted phenyl up to 10 carbon atoms, cycloalkyl or aralkyl up to 10 carbon atoms, followed by hydrogenation and saponification or deetherification.

专利号:US-8759508-B2
优先权日:2007-05-18
标 题 :Chromophoric silyl protecting groups and their use in the chemical synthesis of oligonucleotides
发明人：DELANEY MICHAEL OREN
权利人:DELANEY MICHAEL OREN; GE HEALTHCARE DHARMACON INC
摘要:The compounds are of class of chromophoric 1,2,3-triazolyl equipped silyl linking groups that are useful in the chemical synthesis of RNA. An example of a nucleoside comprising this group is