专利号:US-4056573-A 优先权日:1975-04-24 标题:Synthesis of acyclic, terpene alcohols 发明人:CLOSE RALPH E; DERFER JOHN M 权利人:SCM CORP 摘要:Shown is a process for the synthesis of acyclic, terpene alcohols, such as 3,7-dimethyloctan-1-o1 and 7-substituted hydroxy or ethoxy derivatives thereof, wherein 3-methylbut-1-yn or the 3-substituted hydroxy or ether derivative thereof is coupled with a C5 coupling reagent having the configuration X being a leaving group such as chloride, bromide, iodide, tosylate and mesylate; R being or OR', R' being a lower alkyl up to 5 carbon atoms, phenyl, substituted phenyl up to 10 carbon atoms, cycloalkyl or aralkyl up to 10 carbon atoms, followed by hydrogenation and saponification or deetherification.
专利号:US-10815194-B2 优先权日:2016-11-14 标题 :Process for the preparation of mono-protected α,ω-diamino alkanes 发明人:MENGE WIRO MICHAEL PETRUS BERNARDUS 权利人:BYONDIS BV 摘要:The present invention relates to a process for the synthesis of mono-protected α,ω-diamino alkanes, the use of said process in a process for the synthesis of a linker drug comprising an α,ω-diamino alkane moiety and the use of the process of the present invention in a process for preparing an antibody-drug conjugate comprising an α,ω-diamino alkane moiety.
专利号:US-5786321-A 优先权日:1996-07-09 标题:Preparation of cis-isoambrettolidies and their use as a fragrance 发明人:MANE MAURICE; PONGE JEAN-LOUIS 权利人:MANE V FILS SA 摘要:A method for the production of omega -haloalkyl esters which are useful as intermediates in the synthesis of cis-oxacycloheptadec-11-en-2-one (Product I) and cis-oxacycloheptadec-12-en-2-one (Product II). Also disclosed is a process for the synthesis of Products I-II and a method for using Products I-II to impart an ambery or musky smell to a fragrance composition. Finally, fragrance compositions including Products I-II are disclosed as well as end products such as perfume extracts, toilet waters, cosmetic preparations, soaps, detergents and functional products, each of which also contains at least one of Products I-II.
专利号:US-3962354-A 优先权日:1970-06-24 标题 :Synthesis of cis-3-hexen-1-ol 发明人:DAHILL JR ROBERT T 权利人:GIVAUDAN CORP 摘要:There is provided a novel method of preparing the highly desired odorant cis-3-hexen-1-ol from alkyl phenyl ethers. The method comprises Birch reduction of the alkyl phenyl ether, sequentially followed by oxidative ring cleavage and reduction.
专利号:US-2019276389-A1 优先权日:2015-12-18 标题:Synthesis of aryl cyclohexane ester derivatives useful as sensates in consumer products 发明人:WOS JOHN AUGUST; YELM KENNETH EDWARD; BUNKE GREGORY MARK; FREDERICK HEATH ALAN; REILLY MICHAEL; HAUGHT JOHN CHRISTIAN; SREEKRISHNA KOTI TATACHAR; LIN YAKANG 权利人:PROCTER & GAMBLE 摘要:Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.
专利号:US-2010240923-A1 优先权日:2007-11-29 标题:Enzymatic synthesis of (meth)acrylic esters of hydroxy-functional aromas 发明人:HAERING DIETMAR; WINTER GABI; SCHNELLER ARNOLD; AULENTA FRANCESCA 权利人:BASF SE 摘要:A process for preparing (meth)acrylic esters (F) of hydroxy-functional aromas (A), in which at least one hydroxy-functional aroma (A) in the presence of at least one enzyme (E) is esterified with (meth)acrylic acid (S), or transesterified with at least one (meth)acrylic ester (D), the reaction in the case of the transesterification being effected in the absence of solvents.