专利号:WO-2024084510-A1 优先权日:2022-10-20 标题 :Glutamic acid independent process for synthesis of poly gamma glutamic acid 发明人:DHARNE MAHESH SHANTAPPA; NAIR PRANAV GIRIJAVALLABHAN 权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S 摘要:The present invention relates to a cost-effective process for the synthesis of hyper-production of poly gamma glutamic acid using L-glutamic acid independent approach. Specifically, the present invention relates to the synthesis of poly gamma glutamic acid (γ-PGA) from jaggery, blackstrap molasses, and floral waste. More particularly, the present invention relates to a process for the synthesis of poly gamma glutamic acid in high yield and in the presence of Bacillus paralicheniformis NCIM 5769.
专利号:WO-2025037328-A1 优先权日:2023-08-11 标题:A method for synthesis of rare-earth oxychloride and production of rare-earth metal/alloy 发明人:BORRA PROF CHENNA RAO; LAKSHMI BORRA VENKATA; JANA DR PRASANTA; ROUT SONALI 权利人:INDIAN INSTITUTE OF TECH KHARAGPUR 摘要:The present disclosure relates to a method for external synthesis of rare-earth oxychloride and production of rare-earth metal or alloy. The method comprises the steps of adding hydrochloric acid (HCl) to a portion of a pre-defined weight of rare-earth oxide (RE2O3) converting the portion of RE2O3 to rare-earth chloride hydrate (RECl3.xH2O). The method further comprises mixing the residual rare-earth oxide (RE2O3) with the RECl3.xH2O and heating the mixture to a temperature exceeding 300℃ to obtain rare-earth oxychloride (REOCl). The method includes making the obtained REOCl to react directly with a reductant or mixture of reductant and alloying element in a temperature of 600℃ - 1400℃ for reducing the rare-earth oxychloride (REOCl) to rare-earth metal or alloy; and upon cooling, treating the reduced mass of rare-earth metal or alloy with water and dilute acid to remove reaction byproducts such as calcium chloride (CaCl2) and calcium oxide (CaO).
专利号:US-4078331-A 优先权日:1976-04-28 标题:Process and culture composition for growth of alga and synthesis of biopolymer 发明人:SAVINS JOSEPH GEORGE; PAUL JAMES M 权利人:MOBIL OIL CORP 摘要:This specification discloses a process and a culture composition for growth of an alga and synthesis of biopolymer by the alga. The process involves growth of the alga and concomitant synthesis of the biopolymer in an aqueous culture containing as a source of phosphate for said alga dibasic sodium or dibasic potassium phosphate. The nitrogen source can be sodium nitrate or urea. Control of the pH of the culture is effected by injecting a mixture of carbon dioxide and air into the culture during growth of the alga and synthesis of the biopolymer. The carbon dioxide also serves as a source of carbon for growth of the alga and synthesis of the biopolymer and provides agitation/mixing within the culture chamber. Preferably, the mixture of carbon dioxide and air is injected continuously into the culture during the entire growth period of the alga.
专利号:US-6660305-B1 优先权日:1998-07-28 标题 :Composition for stimulating the synthesis of the melanic pigment and process for obtaining it 发明人:CAO CARLOS M MIYARES 权利人:CT DE HISTOTERAPIA PLACENTARIA 摘要:This invention relates to the field of human medicine, more specifically to dermatology, and in particular to a composition developed for the stimulation of the synthesis of the melanic pigment of the skin, therefore useful for the treatment of vitiligo. The technical goal of this invention is to provide a composition of natural origin useful in the treatment of vitiligo that has no toxic effects and no relapse. The composition obtained stimulates the synthesis of the melanic pigment of the skin and the reproduction of melanocytes, as demonstrated through pharmacological tests to which the composition was subjected, causing no serious secondary reactions at all, as demonstrated in the toxicological, teratological and clinical tests performed. The resulting product can easily be obtained and applied, repigmentation begins rapidly after initiating the treatment, and the effect is irreversible. The color acquired is identical to the color of the normal skin areas of the patient, but these areas do not further increase the intensity of their coloration after the product has been applied. The product can also be used for the treatment of any depigmentation process of the skin, for example, that caused by burns.
专利号:US-2007066835-A1 优先权日:2003-03-24 标 题:Process for the synthesis of amorphous atorvastain calcium 发明人:CZIBULA LASZLO; DOBAY LASZLO; PAPP EVA W; JUHASZ IDA D; BALINT SANDORNE 权利人:CZIBULA LASZLO; DOBAY LASZLO; PAPP EVA W; JUHASZ IDA D; BALINT SANDORNE 摘要:The invention relates to a new process for the synthesis of amorphous atorvastatin calcium, which consists of dissolving the salt of the formula (I) of atorvastatin acid formed with a basic amino acid (I); in a mixture of water and a water miscible organic solvent, adding an aqueous solution of a water soluble calcium salt to the solution and isolating the so obtained entirely amorphous atorvastatin calcium of high purity by filtration.
专利号:US-12221421-B2 优先权日:2019-03-19 标题:Process for synthesis of Fipronil 发明人:GHARDA KEKI HORMUSJI; SHENOY DIWAKAR; SHET LAXMINARAYAN; SAMANGADKAR YATIN; KAWADE ABHIJEET SURESH 权利人:GHARDA CHEMICALS LTD 摘要:A process for the synthesis of fipronil, which is a broad spectrum insecticide of the following chemical structure, is provided.The process provides fipronil with a yield in the range of 75% to 90% and purity in the range of 95% to 97%. By the process, the observed amount of sulfone impurity i.e., 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoro methylsulfonyl pyrazole in fipronil is in the range of 0% to 0.5%.
[参考文献]: Amritlal Mandal, Et Al. Calcium Entry Via Connexin Hemichannels In Lens Epithelium. Exp Eye Res. 2015 Mar:132:52-8. [参考文献]: Ashleigh M Byrne, Et Al. The Activity Of Camp-Phosphodiesterase 4D7 (Pde4D7) Is Regulated By Protein Kinase A-Dependent Phosphorylation Within Its Unique N-Terminus. Febs Lett. 2015 Mar 12;589(6):750-5. [参考文献]: Chancievan Thangaratnarajah, Et Al. Calcium-Induced Conformational Changes Of The Regulatory Domain Of Human Mitochondrial Aspartate/glutamate Carriers. Nat Commun. 2014 Nov 20:5:5491. [参考文献]: Erin R Gaddes, Et Al. Aptamer-Based Polyvalent Ligands For Regulated Cell Attachment On The Hydrogel Surface. Biomacromolecules. 2015 Apr 13;16(4):1382-9. [参考文献]: Jing Cao, Et Al. Loading And Release Mechanism Of Red Clover Necrotic Mosaic Virus Derived Plant Viral Nanoparticles For Drug Delivery Of Doxorubicin. Small. 2014 Dec 29;10(24):5126-36.
合成参考文献
参考文献:10.1107/s0909049509055319 摘要:Siritapetawee J, Pattanasiriwisawa W, Sirithepthawee U. Trace element analysis of hairs in patients with dementia. J Synchrotron Radiat. 2010 Mar;17(2):268–72. doi: 10.1107/s0909049509055319. 参考文献:10.1016/j.joen.2011.05.009 摘要:Gandolfi MG, Shah SN, Feng R, Prati C, Akintoye SO. Biomimetic Calcium-Silicate Cements Support Differentiation of Human Orofacial Mesenchymal Stem Cells. Journal of Endodontics. 2011 Aug;37(8):1102–8. doi: 10.1016/j.joen.2011.05.009. 摘要:Sedykh NV, Beliaeva MI, Leshchinskaya IB. [Effect of bivalent metal ions and EDTA on the activity and dielectric properties of the deoxyribonuclease of Bacillus amylozyma and Serratia marcescens]. Biofizika. 1967 May;12(3):546–9. 参考文献:10.1166/jnn.2011.3883 摘要:Nirmala R, Kang HS, El-Newehy MH, Navamathavan R, Park HM, Kim HY. Human osteoblast cytotoxicity study of electrospun polyurethane/calcium chloride ultrafine nanofibers. J Nanosci Nanotechnol. 2011 Jun;11(6):4749–56. doi: 10.1166/jnn.2011.3883. 参考文献:10.1186/1746-6148-7-39 摘要:Jana K, Samanta PK. Clinical Evaluation of Non-surgical Sterilization of Male Cats with Single Intra-testicular Injection of Calcium Chloride. BMC Veterinary Research. 2011 Jul 21;7(1):39. doi: 10.1186/1746-6148-7-39.