CAS: 99277-71-1; 4-Bromo-2-Nitrobenzoic Acid

上下游产品

CAS号610-36-6 4-氨基-2-硝基苯甲酸 | CAS号5551-12-2 4-溴-2-硝基苯甲醛 | CAS号106-38-7 对溴甲苯 | CAS号79603-03-5 4-溴-2-硝基苯甲腈 | CAS号875-51-4 4-溴-2-硝基苯胺 | CAS号88-72-2 邻硝基甲苯 | CAS号3460-18-2 2,5-二溴硝基苯 | CAS号552-16-9 2-硝基苯甲酸 | CAS号20776-50-5 2-氨基-4-溴苯甲酸 | CAS号890315-72-7 4-溴-2-硝基苯甲酸叔丁酯 | CAS号158580-57-5 2-硝基-4-溴苯甲酸甲酯 | CAS号27329-27-7 4-甲基-2-硝基苯甲酸 | CAS号16588-24-2 5-溴-2-氯硝基苯 | CAS号194851-16-6 7-溴-3,4-二氢喹唑啉-4-酮 | CAS号112734-21-1 4-溴-2-硝基苯甲酰氯 | CAS号1224724-39-3 4-溴-1H-吲哚-7-羧酸甲酯

4-溴-2-硝基苯甲醛置于jones Reagent体系中,用 丙酮 作为反应溶剂,化学反应生成 4-溴-2-硝基苯甲酸
参考文献:Quinazoline Derivatives
标题:Quinazoline Derivatives
摘要:式(i)的化合物或其药学上可接受的盐,水合物,溶剂合物,光学活性化合物,消旋体或其二对映异构体混合物具有优越的酪氨酸特异性蛋白激酶抑制活性,并且可用作药物剂,特别是作为各种癌症,银屑病或由动脉硬化引起的疾病的预防或治疗剂.

专利信息

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.