CAS: 93117-08-9; 5-Aminoisoquinolin-1(2H)-One
该化合物是一种有机化合物,其特点是其同位素结构,其特点是一个含有氮原子的引信双环系统,该化合物因其氨基氨基氨基(-NH2)和一个有助于其反应和潜在生物活动的Keto(C=O)组而显著可见,它通常看起来像一种晶状固体,在极地溶剂中可以溶解,反映其功能组;氨基质组的存在允许氢结合,这可以加强其在生物系统中的互动. 5-Amino-1(2H)-isoquinolineone由于其在药物开发中的潜在应用,特别是在针对特定生物途径的应用,因此对医药化学产生了兴趣,其分子结构表明它可能具有多种药用特性,使其成为诸如药用化学和生物化学学等领域的研究对象.与许多有机化合物一样,应当观察安全和处理预防措施,因为其生物影响和毒性特征是其应用中的基本考虑因素.
- 英文名称5-Aminoisoquinolin-1(2H)-One
- 中文名称5-氨基-1(2H)-异喹啉酮
- IUPAC名称5-aminoisoquinolin-1(2H)-one
- 其它别名5-Amino-2H-Isoquinoin-1-One; 1(2H)-Isoquinolinone,5-Amino-; 4Pnq; 5-Amino-1,2-Dihydroisoquinolin-1-One; 5-Amino Isoquinolin-1(2H)-One; 8V3G4R3Qnx; 32X; 5-Amino-2H-Isoquinolin-1-One; B
- CAS编号93117-08-9
- MFCD编号:MFCD06198896
- EINECS号:801-002-1
- FDA UNII编号:8V3G4R3QNX
- 分子式:C9H8N2O
- 分子量:160.17
- 产品CID: 1969876
- 产品分类有机原料→分子砌块→芳杂环类化合物→异喹啉类化合物
相似化合物
82827-08-5 174302-46-6 93117-07-8物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号82827-08-5 5-硝基异喹啉-1(2H)-酮 | CAS号7440-44-0 活性炭合成工艺路线路线简述
- 合成目标产物 5-Amino-2H-Isoquinolin-1-One 主要起始原料 5-Nitro-1(2H)-Isoquinolinone
- 82827-08-5 = 93117-08-9
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 18 H,Rt
标题:Discovery Of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists And Antagonists And The Structural Elucidation Of Their Activity Shift
作者:Thorat,Shivaji A.; Lee,Yoonji; Jung,Aeran; Ann,Jihyae; Ahn,Songyeon; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2021 卷标:64(1) 页码:370-384]
82827-08-5 = 93117-08-9
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Dimethylformamide; Overnight,50 °C
标题:Preparation Of N-Heterocyclyl- And N-Aryl-5,5-Diphenylpentadienamide Derivatives As Antagonists Of Transient Receptor Potential Vanilloid (Trpv1)
参考文献:World Intellectual Property Organization]
82827-08-5 = 93117-08-9
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: 1,4-Dioxane; 4 H,Rt
标题:Preparation Of Fused Heterocyclic Carbonohydrazonoyl Dicyanide Compound For Inhibiting Aggregation And/or Hyperphosphorylation Of Tau Protein
参考文献:World Intellectual Property Organization]
= 93117-08-9 [标题:Reaction Conditions
标题:Preparation Of 1-(Hetero)Arylamino-1,2,3,4-Tetrahydronaphthalenes As Antiinflammatories.
参考文献:World Intellectual Property Organization]
= 93117-08-9 [标题:Reaction Conditions
标题:Aryl Nitroso Compounds As Specific Inactivators Of Retroviral (Asymmetric) Zinc Fingers And As Anti-Tumor Agents
参考文献:United States]
82827-08-5 = 93117-08-9
反应条件:1.1 Reagents: Zinc,Ammonium Chloride Solvents: Ethanol,Tetrahydrofuran,Water; Rt -> 35 °C; 2 H,35 °C
标题:Preparation Of Quinoline And Related Compounds For Use As Anti-Inflammatory Agents
参考文献:World Intellectual Property Organization]
82827-08-5 = 93117-08-9
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Dimethylformamide; Overnight,50 °C
标题:Pentadienamide Derivatives As Vanilloid Receptor Inhibitors And Their Preparation And Use In The Treatment Of Diseases
参考文献:United States]
82827-08-5 = 93117-08-9
反应条件:1.1 Reagents: Zinc,Ammonium Chloride Solvents: Ethanol,Tetrahydrofuran,Water; Rt -> 35 °C; 2 H,30 - 35 °C
标题:Preparation Of Tetrahydronaphthalene Derivatives As Anti-Inflammatory Agents
参考文献:United States]
= 93117-08-9 [标题:Reaction Conditions
标题:Preparation Of 4-Methyl-4-Penten-1-Amines And Related Compounds As Antiphlogistics
参考文献:World Intellectual Property Organization]
= 93117-08-9 [标题:Reaction Conditions
标题:Effects Of 5-Aminoisoquinolinone,A Water-Soluble,Potent Inhibitor Of The Activity Of Poly (Adp-Ribose) Polymerase On The Organ Injury And Dysfunction Caused By Hemorrhagic Shock
作者:Mcdonald,Michelle C.; Mota-Filipe,Helder; Wright,James A.; Abdelrahman,Maha; Threadgill,Michael D.; Et Al
参考文献:British Journal Of Pharmacology 日期:2000 卷标:130(4) 页码:843-850]
= 93117-08-9 [标题:Reaction Conditions
标题:Adenosine Diphosphoribose Polymerase Binding Nitroso Aromatic Compounds Useful As Retroviral Inactivating Agents,Anti-Retroviral Agents And Anti-Tumor Agents
参考文献:United States]
= 93117-08-9 [标题:Reaction Conditions
标题:Preparation Of Substituted Dihydroisoquinolinones And Related Compounds As Radiation Therapy Potentiators And Chemotherapeutic Agents
参考文献:European Patent Organization]
491-30-5 = 93117-08-9 + 174302-46-6
反应条件:1.1 -1.2 Reagents: Potassium Hydride Catalysts: Palladium Solvents: Methanol
标题:Synergistic Antiviral And Antitumor Compositions Of Poly(Adp Ribose)Transferase (Padprt) Cchc-Oxidizing Ligands And Noncovalent Padprt-Inhibitory Ligands
参考文献:United States
5-硝基-1(2H)-异喹啉酮置于palladium-Carbon Silica Gel体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 16.0H,以to Give 5-Amino-2H-Isoquinolin-1-One (620 Mg,70%)的收率获得产物5-氨基-1(2H)-异喹啉酮
参考文献:Pentadienamide Derivatives
标题:Pentadienamide Derivatives
摘要:本发明提供了一种由以下公式(i)表示的五二烯酰胺衍生物:(其中,R1代表取代或未取代的芳基或取代或未取代的芳香杂环基;r2代表取代或未取代的芳基,取代或未取代的芳香杂环基,取代或未取代的杂环螺环基或类似物;r3代表氢原子或与r4及其相邻的氮原子结合形成取代或未取代的杂环基;r4代表取代或未取代的芳基,取代或未取代的芳香杂环基,取代或未取代的杂环螺环基或类似物,或与r3及其相邻的氮原子结合形成取代或未取代的杂环基;r5,R6和r7可以相同也可以不同,每个代表氢原子或甲基)或其药学上可接受的盐等.
海关参考信息
- 2933310010-吡啶
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2014063189-A1
优先权日:2012-10-23
标题 :Methods and products for preventing and/or treating a stress induced cardiomyopathy
发明人：HOROWITZ JOHN; CHIRKOV YULIY
权利人:ADELAIDE RES & INNOVATION PTY
摘要:The present disclosure relates to methods and products for preventing and/or treating a stress- induced cardiomyopathy. Certain embodiments of the present disclosure provide a method of preventing and/or treating a stress-induced cardiomyopathy in a subject, the method comprising administering to the subject a therapeutically effective amount of one or more of the following agents: a peroxynitrite inhibitor; an inhibitor of peroxynitrite synthesis; an inhibitor of peroxynitrite associated signalling; an inhibitor of peroxynitrite-induced DNA damage; a Tx NIP inhibitor; a beta 2 adrenoceptor antagonist; and a beta 3 adrenoceptor antagonist; thereby preventing and/or treating the stress-induced cardiomyopathy in the subject.
网址: http://www.tbbmed.com
电话: 021-50498136 13564881053👤
销售电话:021-50498136 13564881053
邮箱：products@tbbmed.com
电话: 021-50498136 13564881053👤
📞上海晋鲁医药科技有限公司 ⚠️参考联系方式
销售电话:021-50498136 13564881053
邮箱：products@tbbmed.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→
⚠️ 未注册 · 未认证企业
备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。第 1 / 1 页
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
[参考文献]: Mota-Filipe H, Et Al. The Novel Parp Inhibitor 5-Aminoisoquinolinone Reduces The Liver Injury Caused By Ischemia And Reperfusion In The Rat. Med Sci Monit. 2002 Nov;8(11):Br444-53.[参考文献]: Vinod Kr, Chandra S, Sharma Sk. Evaluation Of 5-Aminoisoquinoline (5-Aiq), A Novel Parp-1 Inhibitor For Genotoxicity Potential In Vitro And In Vivo. Toxicol Mech Methods. 2010 Feb;20(2):90-5.
合成参考文献
参考文献:10.18632/aging.100052
摘要:Altmeyer M, Hottiger MO. Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging. Aging (Albany NY). 2009 May 20;1(5):458–69.
📝 需求与反馈
尽可能描述清楚需求与问题信息
