CAS: 914070-99-8; (S)-1-(2-Aminoacetyl)Pyrrolidine-2-Carbonitrile

英文名称(S)-1-(2-Aminoacetyl)Pyrrolidine-2-Carbonitrile
中文名称维格列汀杂质A
IUPAC名称(S)-1-glycylpyrrolidine-2-carbonitrile
其它别名Vildagliptin Impurity 12/(S)-1-Glycylpyrrolidine-2-Carbonitrile; 2-Pyrrolidinecarbonitrile, 1-(2-Aminoacetyl)-, (2S)-; (S)-1-Glycylpyrrolidine-2-Carbonitrile; (S)-1-Glycylpyrrolidine-2-Carbonitrile (Vildagliptin Impurity）; (S)-1-(2-Aminoacetyl)Pyrrolidine-2-Carbonitrile
CAS编号914070-99-8
MFCD编号:MFCD30530017
分子式:C7H11N3O分子量:153.18
产品CID: 1949760
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: XDOMURQNGATABE-LURJTMIESA-N
InChI=1S/C7H11N3O/c8-4-6-2-1-3-10(6)7(11)5-9/h6H,1-3,5,9H2/t6-/m0/s1
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

MSDS等安全信息

上下游产品

(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide L-prolineL-proline (S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid L-prolinamide

合成工艺路线路线简述

207557-35-5 = 914070-99-8
反应条件:1.1 Reagents: Ammonium Hydroxide; -20 °C; 3 H,-20 °C -> Rt
标题:Direct Synthesis Of Cyanopyrrolidinyl -Amino Alcohols For The Development Of Novel Diabetes Therapeutics
作者:Lizza,Joseph R.; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2016 卷标:2016(30) 页码:5160-5168]

23500-10-9 = 914070-99-8
反应条件:1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Dichloromethane; 5 Min,0 °C; 0 °C -> Rt; 1 H,Rt1.2 Reagents: Ammonium Bicarbonate; 1 H,Rt; 6 H,Rt2.1 Reagents: Trifluoroacetic Anhydride Solvents: Tetrahydrofuran; 1 H,0 °C; 0 °C -> Rt; 6 H,Rt3.1 Reagents: Ammonium Hydroxide; -20 °C; 3 H,-20 °C -> Rt
标题:Direct Synthesis Of Cyanopyrrolidinyl -Amino Alcohols For The Development Of Novel Diabetes Therapeutics
作者:Lizza,Joseph R.; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2016 卷标:2016(30) 页码:5160-5168]

952023-06-2 = 914070-99-8
反应条件:1.1 Reagents: P-Toluenesulfonic Acid
标题:Inhibitor-Decorated Polymer Conjugates Targeting Fibroblast Activation Protein
作者:Dvorakova,Petra; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2017 卷标:60(20) 页码:8385-8393]

214398-99-9 = 914070-99-8
反应条件:1.1 Reagents: Trifluoroacetic Anhydride Solvents: Tetrahydrofuran; 1 H,0 °C; 0 °C -> Rt; 6 H,Rt2.1 Reagents: Ammonium Hydroxide; -20 °C; 3 H,-20 °C -> Rt
标题:Direct Synthesis Of Cyanopyrrolidinyl -Amino Alcohols For The Development Of Novel Diabetes Therapeutics
作者:Lizza,Joseph R.; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2016 卷标:2016(30) 页码:5160-5168]

79-04-9 + 147-85-3 = 914070-99-8
反应条件:1.1 Solvents: Tetrahydrofuran; Rt; 6 H,Rt -> Reflux; Reflux -> Rt1.2 Reagents: Water; 30 Min,Rt2.1 Reagents: Dicyclohexylcarbodiimide Solvents: Dichloromethane; 5 Min,0 °C; 0 °C -> Rt; 1 H,Rt2.2 Reagents: Ammonium Bicarbonate; 1 H,Rt; 6 H,Rt3.1 Reagents: Trifluoroacetic Anhydride Solvents: Tetrahydrofuran; 1 H,0 °C; 0 °C -> Rt; 6 H,Rt4.1 Reagents: Ammonium Hydroxide; -20 °C; 3 H,-20 °C -> Rt
标题:Direct Synthesis Of Cyanopyrrolidinyl -Amino Alcohols For The Development Of Novel Diabetes Therapeutics
作者:Lizza,Joseph R.; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2016 卷标:2016(30) 页码:5160-5168

📜(S)-1-(2-氯乙酰基)吡咯烷-2-羧酰胺置于三氟乙酸酐,Ammonium Hydroxide体系中,用四氢呋喃作为反应溶剂,化学反应 9.0H,反应生成维格列汀杂质a
参考文献:用于开发糖尿病治疗药物的氰基吡咯烷基 β-氨基醇的直接合成
标题:用于开发糖尿病治疗药物的氰基吡咯烷基 β-氨基醇的直接合成
摘要:氰基吡咯烷基 β-氨基醇是具有广泛药理特性潜力的新型支架.我们已经发现,我们可以通过很少的合成步骤从简单且廉价的市售化学品中选择性地获取这些支架,并且纯化最少.我们已经制作了这些支架的 36 化合物库,并将它们作为二肽基肽酶 Iv (Dpp4) 抑制剂进行了测试.这些新型抑制剂可用于治疗糖尿病和炎性疾病.
DOI:10.1002/ejoc.201600969