专利号:US-12415828-B2 优先权日:2014-08-22 标题:Modified oligonucleotides and methods for their synthesis 发明人:STETSENKO DMITRY; KUPRYUSHKIN MAXIM; PYSHNYI DMITRII 权利人:NOOGEN LLC 摘要:Modified oligonucleotides that contain one or more of the phosphate groups substituted at phosphorus and methods for their synthesis are disclosed.
专利号:CN-102532199-A 优先权日:2012-02-29 标 题:Structure and Synthesis of Novel Benzyl Phosphoramidate Prodrugs of Nucleoside Compounds
专利号:JP-2005510480-A 优先权日:2001-10-05 标 题:Stereoselective synthesis of 2-hydroxymethyl-chroman
专利号:JP-2005509613-A 优先权日:2001-10-05 标题:Stereospecific synthesis of 2-ylchroman derivatives
专利号:JP-4425352-B2 优先权日:1997-02-10 标 题 :Synthesis of acyclic nucleoside derivatives.
专利号:WO-2013154753-A1 优先权日:2012-04-12 标题:Hydrolytically degradable poly (ethylene glycol) derivatives through introduction of unsaturated methylene ethylene oxide repeat units 发明人:HAWKER CRAIG J; LYND NATHANIEL A; VAN DEN BERG SEBASTIAN; LEE BONGJAE F; LUNDBERG PONTUS; PRESSLY ERIC D 权利人:UNIV CALIFORNIA 摘要:Reactive and hydrolytically-degradable poly(alkylene oxide) derivatives and methods for their synthesis are described herein. These polymers differ from poly(alkylene oxide) by the controlled incorporation of degradable repeat units together with alkylene oxide units. The degradable polymers contain vinyl ether degradable units (e.g., methylene ethylene oxide) incorporated into a polyalkylene backbone (e.g., ethylene oxide, propylene oxide, butylene oxide, other alkylene oxides, glycidol, methyl glycidyl ether, ethyl glycidyl ether, allyl glycidyl ether, or other repeat units derived among the glycidyl ethers). The alkylene oxides and glycidyl ethers may be racemic mixtures, enantiomerically enriched, or enantiomerically pure. The degradable polymers disclosed herein can be used in applications where hydrolytic degradability under physiological, or physiological-like conditions is desirable, such as pharmaceutical and cosmetic formulations and degradable devices.