CAS: 6999-19-5; 4-(Trimethylsilyl)But-3-Yn-2-Ol

上下游产品

methyl magnesium iodide 3-(trimethylsilyl)prop-2-yn-1-al chloro-trimethyl-silane but-3-yn-2-ol 4-trimethylsilyl-3-butyn-2-one (R)-4-trimethylsilyl-3-butyn-2-yl acetate (S)-4-trimethylsilyl-3-butyn-2-ol 4-trimethylsilylbut-3-yn-2-yl N-phenylcarbamate

📜3-丁炔-2-醇置于盐酸,正丁基锂,三甲基氯硅烷体系中,用 甲醇,正己烷,水 作为反应溶剂,化学反应生成 4-三甲基硅-3-丁炔-2-醇
参考文献:Dimethylfurano Heterocyclic Analogs Of Daunomycin
标题:Dimethylfurano Heterocyclic Analogs Of Daunomycin
摘要:描述了daunomycin的dimethyfurano类似物,包括(.+-.)-8.Alpha.-乙酰基-6,7,8,9-四氢-5,6.Beta.,8.Beta.,10-四羟基-1,3-二甲基-蒽[2,3-C]-呋喃-4,11-二酮-6-(3-氨基-2,3-6-三脱氧-.Alpha.-L-利索-己糖苷),这些类似物对哺乳动物的癌症治疗具有用处,如黑色素瘤,鳞状细胞癌,骨髓瘤和胰腺癌.

专利信息

专利号:US-5849936-A
优先权日:1995-03-15
标题:Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins
发明人：HOYE THOMAS R; TAN LUSHI
权利人:UNIVERISTY OF MINNESOTA
摘要:A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

专利号:US-5739358-A
优先权日:1996-10-03
标题:Synthesis of acetogenins
发明人：HOYE THOMAS R; YE ZHIXIONG
权利人:UNIV MINNESOTA
摘要:A method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enzyme.

专利号:US-4161480-A
优先权日:1978-06-05
标题 :Intermediates for the synthesis of 4-demethoxydaunorubicin
发明人：GARLAND ROBERT B; PAPPO RAPHAEL
权利人:SEARLE G D &
摘要:The present invention encompasses novel intermediates having the following structural formulas: ##STR1## wherein X is hydrogen, methoxy, or hydroxy; ##STR2## wherein X is hydrogen, methoxy, or hydroxy; and ##STR3## wherein X is hydrogen, methoxy, or hydroxy. Compounds of the present invention are useful in synthesizing 4-demethoxydaunorubicin, daunorubicin, adriamycin, and carminomycin which are potent antitumor agents.

专利号:US-5587491-A
优先权日:1995-03-15
标题:Method for the synthesis of bis-tetrahydrofuranyl Annonaceous acetogenins

专利号:CA-1131622-A
优先权日:1978-06-05
标 题 :Intermediates for the synthesis of (.sup. )-4- demethoxydaunorubicin

专利号:CA-1125284-A
优先权日:1978-06-05
标题:Intermediates for the synthesis of ( )-4-demethoxydaunorubicin