CAS: 58569-55-4; 2-[[2-[[2-[[2-[[2-Amino-3-(4-Hydroxyphenyl)Propanoyl]Amino]Acetyl]Amino]Acetyl]Amino]-3-Phenylpropanoyl]Amino]-4-Methylsulfanylbutanoic Acid

上下游产品

CAS号1188307-69-8 (5S,14S,17S)-14... | CAS号59481-77-5 B°C-Met-Enkephalin | CAS号60283-51-4 (Met(O)5)-Enkephalin | CAS号70035-46-0 hydr°Chloride o... | CAS号129398-68-1 B°C-Tyr(Cl2Bzl)... | CAS号1161-13-3 N-苄氧羰基-L-苯丙氨酸 | CAS号4976-72-1 tert-butyl (2S)... | CAS号16874-01-4 benzyl (S)-1-(t... | CAS号82362-13-8 L-Methionine, N... | CAS号82362-12-7 Z-Phe-Met-OBut | CAS号59481-77-5 B°C-Met-Enkephalin

H-Phe-Met-Obut置于钯 茴香硫醚,1-羟基苯并三唑,N,N'-二环己基碳二亚胺,三氟乙酸体系中,用 乙醇,N,N-二甲基甲酰胺,乙腈 作为反应溶剂,化学反应 1.5H,反应生成 蛋氨酸-脑啡呔
参考文献:Amino Acids And Peptides. Vii. Synthesis Of Methionine-Enkephalin Using Transfer Hydrogenation.
标题:Amino Acids And Peptides. Vii. Synthesis Of Methionine-Enkephalin Using Transfer Hydrogenation.
摘要:催化的转移氢化作用通过对几种质子供体的研究,用于去除z-Met-Obut中的z基团.顺式十氢化萘以及环己烯是转移氢化的非常好质子供体.met-脑啡肽通过与leu-脑啡肽相同的路径合成,结合z基团和叔丁酯基团进行保护,通过转移氢化去除z基团.通过测量电刺激引起豚鼠回肠收缩的抑制作用来确定合成肽的生物活性,结果与天然物质的报道结果吻合非常好,表明这种方法可能对合成含met的生物活性肽有用.
DOI:10.1248/cpb.30.581

专利信息

专利号:US-5202418-A
优先权日:1990-02-02
标题 :Method of performing multiple synthesis of peptides on solid carrier

专利号:US-8219327-B2
优先权日:1995-04-25
标 题 :Multiplexed assay using encoded solid support matrices
发明人：NOVA MICHAEL P; SENYEI ANDREW E; PARANDOOSH ZAHRA; DAVID GARY S; XIAO XIAO-YI
权利人:NOVA MICHAEL P; SENYEI ANDREW E; PARANDOOSH ZAHRA; DAVID GARY S; XIAO XIAO-YI; IRORI TECHNOLOGIES INC
摘要:In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix with a substrate adapted for attachment and/or synthesis of molecules and an integrally-formed memory device with an optically-encoded identifier to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions then placed within the path of an optical detector adapted to read the optically-encoded identifier and measure biochemical processes on each support matrix. The support matrices may besingulated to be read by the optical detector one at a time.

专利号:EP-0445915-B1
优先权日:1990-02-02
标题:Method of performing a multiple synthesis of peptides on a solid carrier and apparatus for carrying out this method

专利号:US-5338831-A
优先权日:1990-02-02
标 题 :Method of making multiple synthesis of peptides on solid support

专利号:EP-0445915-A1
优先权日:1990-02-02
标 题 :Method of performing a multiple synthesis of peptides on a solid carrier and apparatus for carrying out this method

专利号:WO-9012883-A1
优先权日:1989-04-24
标题:Enzymatic membrane method for the synthesis and separation of peptides