CAS: 58569-55-4; 2-[[2-[[2-[[2-[[2-Amino-3-(4-Hydroxyphenyl)Propanoyl]Amino]Acetyl]Amino]Acetyl]Amino]-3-Phenylpropanoyl]Amino]-4-Methylsulfanylbutanoic Acid
- 英文名称2-[[2-[[2-[[2-[[2-Amino-3-(4-Hydroxyphenyl)Propanoyl]Amino]Acetyl]Amino]Acetyl]Amino]-3-Phenylpropanoyl]Amino]-4-Methylsulfanylbutanoic Acid
- 中文名称蛋氨酸-脑啡呔
- IUPAC名称(2S,5S,14S)-14-amino-5-benzyl-15-(4-hydroxyphenyl)-2-[2-(methylsulfanyl)ethyl]-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid
- 其它别名Adrenorphin(human), 6-de-L-arginine-7-de-L-arginine-8-de-L-valinamide-; 5-L-Methionine-enkephalin; 5-Methionine enkephalin; Enkephalin,methionine; Human b-endorphin(1-5); L-Methionine-enkephalin; Lupex; Met-enkephalin; Met5-enkephalin; Metenkefalin; Methionine enkephalin
- CAS编号58569-55-4
- MFCD编号:MFCD00076415
- EINECS号:261-335-8
- FDA UNII编号:9JEZ9OD3AS
- 分子式:C27H35N5O7S分子量:573.67
- 产品CID: 1560620
- 同类组份化合物CAS82362-17-2 (acetate)58569-55-4 (free)
- 产品分类生物化工 → 多肽
物理性质
- 熔点174-177 °C
- 沸点1052.9 °C at 760 mmHg
- 闪点590.6 °C
- 密度1.324 g/cm3
- pKa:3.23±0.10(预测)
- PSA:225.25
- LogP:1.8083
- 折射率1.608
- 蒸汽压0 mmHg at 25 °C
- 溶解性DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
- 敏感性白色或类白色粉末，由5个氨基酸组成，顺序为L-酪氨酸、甘氨酸、L-苯丙氨酸、L-甲硫氨酸。
- 外观形态白色冻干的固体
- 储存条件-20°C
- 产品应用该化合物是一种自然发生的,内生类阿麻碱浸泡物,具有相对短时期的类阿胺效应,是两种形式的安克芬,另一种是列伊-ENKEPHALIN,由于安克法林的威力高,而且选用该场地而优于其他内生阿片,因此,乙型苯乙型乙型六氯环己烷被认为是主要内生的类固醇.
上下游产品
CAS号1188307-69-8 (5S,14S,17S)-14... | CAS号59481-77-5 B°C-Met-Enkephalin | CAS号60283-51-4 (Met(O)5)-Enkephalin | CAS号70035-46-0 hydr°Chloride o... | CAS号129398-68-1 B°C-Tyr(Cl2Bzl)... | CAS号1161-13-3 N-苄氧羰基-L-苯丙氨酸 | CAS号4976-72-1 tert-butyl (2S)... | CAS号16874-01-4 benzyl (S)-1-(t... | CAS号82362-13-8 L-Methionine, N... | CAS号82362-12-7 Z-Phe-Met-OBut | CAS号59481-77-5 B°C-Met-Enkephalin合成工艺路线路线简述
📜H-Phe-Met-Obut置于钯 茴香硫醚,1-羟基苯并三唑,N,N'-二环己基碳二亚胺,三氟乙酸体系中,用 乙醇,N,N-二甲基甲酰胺,乙腈 作为反应溶剂,化学反应 1.5H,反应生成 蛋氨酸-脑啡呔
参考文献:Amino Acids And Peptides. Vii. Synthesis Of Methionine-Enkephalin Using Transfer Hydrogenation.
标题:Amino Acids And Peptides. Vii. Synthesis Of Methionine-Enkephalin Using Transfer Hydrogenation.
摘要:催化的转移氢化作用通过对几种质子供体的研究,用于去除z-Met-Obut中的z基团.顺式十氢化萘以及环己烯是转移氢化的非常好质子供体.met-脑啡肽通过与leu-脑啡肽相同的路径合成,结合z基团和叔丁酯基团进行保护,通过转移氢化去除z基团.通过测量电刺激引起豚鼠回肠收缩的抑制作用来确定合成肽的生物活性,结果与天然物质的报道结果吻合非常好,表明这种方法可能对合成含met的生物活性肽有用.
DOI:10.1248/cpb.30.581
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-5202418-A
优先权日:1990-02-02
标题 :Method of performing multiple synthesis of peptides on solid carrier
专利号:US-8219327-B2
优先权日:1995-04-25
标 题 :Multiplexed assay using encoded solid support matrices
发明人：NOVA MICHAEL P; SENYEI ANDREW E; PARANDOOSH ZAHRA; DAVID GARY S; XIAO XIAO-YI
权利人:NOVA MICHAEL P; SENYEI ANDREW E; PARANDOOSH ZAHRA; DAVID GARY S; XIAO XIAO-YI; IRORI TECHNOLOGIES INC
摘要:In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix with a substrate adapted for attachment and/or synthesis of molecules and an integrally-formed memory device with an optically-encoded identifier to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions then placed within the path of an optical detector adapted to read the optically-encoded identifier and measure biochemical processes on each support matrix. The support matrices may besingulated to be read by the optical detector one at a time.
专利号:EP-0445915-B1
优先权日:1990-02-02
标题:Method of performing a multiple synthesis of peptides on a solid carrier and apparatus for carrying out this method
专利号:US-5338831-A
优先权日:1990-02-02
标 题 :Method of making multiple synthesis of peptides on solid support
专利号:EP-0445915-A1
优先权日:1990-02-02
标 题 :Method of performing a multiple synthesis of peptides on a solid carrier and apparatus for carrying out this method
专利号:WO-9012883-A1
优先权日:1989-04-24
标题:Enzymatic membrane method for the synthesis and separation of peptides
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Dizdar N, Kågedal B, Lindvall B. Treatment of Parkinson's disease with NADH. Acta Neurol Scand. 1994 Nov;90(5):345-7.
合成参考文献
摘要:Furui T, Kuwayama A, Kageyama N. [Measurement of methionine-enkephalin-like substance in CSF from normal subjects and patients with pituitary adenoma (author's transl)]. No To Shinkei. 1980 Mar;32(3):305–9.
参考文献:10.1016/0024-3205(80)90282-9
摘要:Duka T, Wüster M, Herz A. Benzodiazepines modulate striatal enkephalin levels via a GABAergic mechanism. Life Sci. 1980 Mar 10;26(10):771–6. doi: 10.1016/0024-3205(80)90282-9.
📝 需求与反馈
尽可能描述清楚需求与问题信息
