CAS: 57294-74-3; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-4-Hydrazono-3,4-Dihydropyrimidin-2(1H)-One

该化合物是一种由糖和氮基聚氨酯组成的核核糖和氮基聚氨酯衍生的化学化合物.该化合物的特性是水合金功能组,该组由氢氨与碳基化合物的反应组成,在此情况下,碳基聚氨基聚碳基化合物; 丁基4-水合金的特征是其潜在的生物活动,特别是核核糖类比,可影响各种生物化学途径.它可能表现出抗病毒或抗癌活动等特性,尽管具体的机制和功效可能有所不同.该化合物通常在药用化学和药理学方面进行研究,其与生物目标的相互作用是有意义的.此外,其溶性,稳定性和再活性可能受到周围pH的影响,其他化学物种的存在.同许多氢共氮一样,它也可能对氧化敏感,在某些条件下还可能发生进一步反应.

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3258-02-4 2492423-29-5 13491-41-3

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CYTIDINE

合成工艺路线路线简述

    📜胞苷置于sodium Dihydrogenphosphate,一水合肼,Sodium Hydrogensulfite体系中,用 水 作为反应溶剂,化学反应 4.5H,以29%的收率获得产物n4-氨基胞苷
    参考文献:An Improved Synthesis Of N4-Aminocytidine.
    标题:An Improved Synthesis Of N4-Aminocytidine.
    摘要:N4-氨基胞苷,一种诱变核苷,是通过胞苷与由肼,亚硫酸氢盐和ph 7的磷酸盐缓冲液组成的试剂混合物反应后以晶体形式获得的.该产物可直接从反应混合物中沉淀出来,因此该方法适用于大量制备n4-氨基胞苷.
    DOI:10.1248/cpb.35.3884

    海关参考信息

    专利信息


    专利号:US-7541455-B2
    优先权日:2003-12-22
    标题:Microwave mediated synthesis of nucleic acid probes
    发明人：BIENIARZ CHRISTOPHER; FARRELL MICHAEL; KOSMEDER JEROME W; LEFEVER MARK
    权利人:VENTANA MED SYST INC
    摘要:A method for preparing a nucleic acid probe is provided. The method comprises forming an activated cytosine or cytidine by a bisulfite catalyzed reaction; and covalently linking a reporter molecule to the activated cytosine or cytidine, wherein said activating step, said covalently linking step, or both are conducted in the presence of microwave energy. Also provided by the invention are nucleic acid probes.

    专利号:WO-2005064018-A2
    优先权日:2003-12-22
    标题:Microwave mediated synthesis of nucleic acid probes

    专利号:US-11939363-B2
    优先权日:2017-02-28
    标题:Translatable molecules and synthesis thereof
    发明人：LIMPHONG PATTRARANEE; TACHIKAWA KIYOSHI; CHIVUKULA PADMANABH; MATSUDA DAIKI; CALE ARISA
    权利人:ARCTURUS THERAPEUTICS INC
    摘要:A range of therapeutic mRNA molecules expressible to provide a target polypeptide or protein. The RNA molecules can contain one or more 5-methoxyuridines and 5-methylcytidines. Further provided are DNA templates, which can be transcribed to provide a target mRNA, and can have altered nucleotides, such as reduced deoxyadenosines. Also provided are processes for making the therapeutic mRNA molecules. The RNA molecules can be translated in vitro or in vivo to provide an active polypeptide or protein. The RNA molecules can be included in a composition used for preventing, treating, or ameliorating at least one symptom of a disease or condition in a subject in need thereof.

    专利号:US-2005158770-A1
    优先权日:2003-12-22
    标题:Microwave mediated synthesis of nucleic acid probes

    专利号:EP-3630985-B1
    优先权日:2017-05-31
    标题 :Synthesis and structure of high potency rna therapeutics

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    主要参考文献

    [参考文献]: K Negishi, Et Al. [参考文献]: Yakugaku Zasshi. 1990 May;110(5):293-303.
    [参考文献]: K Negishi, Et Al. An Improved Synthesis Of N4-Aminocytidine. Chem Pharm Bull (Tokyo). 1987 Sep;35(9):3884-7.
    [参考文献]: K Negishi, Et Al. Binding Specificities Of The Mismatch Binding Protein, Muts, To Oligonucleotides Containing Modified Bases. Nucleic Acids Res Suppl. 2001:(1):221-2.
    [参考文献]: K Negishi, Et Al. Mutagenesis By N4-Aminocytidine: Induction Of At To Gc Transition And Its Molecular Mechanism. Biochemistry. 1985 Dec 3;24(25):7273-8.
    [参考文献]: K Negishi, Et Al. Mutagenic Nucleoside Analog N4-Aminocytidine: Metabolism, Incorporation Into Dna, And Mutagenesis In Escherichia Coli. J Bacteriol. 1988 Nov;170(11):5257-62.

    合成参考文献


    参考文献:10.1134/s0026893325700402
    摘要:Zernov N, Melenteva D, Popugaeva E. Benzopyran Derivative Improves Synaptic Plasticity, Exploration Interest and Alleviates Amyloidogenesis and Astrogliosis in 5×FAD Mice. Mol Biol. 2025 Nov 17;59(6):964–80. doi: 10.1134/s0026893325700402.
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