CAS: 5610-40-2; (6S,11Ar,11Bs)-9,10,11,11A-Tetrahydro-8H-6,11B-Methanofuro[2,3-C]Pyrido[1,2-A]Azepin-2(6H)-One

上下游产品

RS)-1-formyl-2-((7aSR)-6ξ-bromo-2-oxo-6,7-dihydro-2H-benzofuran-7ar-yl)-piperidine(RS)-1-formyl-2-((7aSR)-6ξ-bromo-2-oxo-6,7-dihydro-2H-benzofuran-7ar-yl)-piperidine 1(S)-[1'-tert-butoxycarbonyl-2'(R)-piperidinyl]-3-bromo-9-oxa-8-oxobicyclo[4.3.0]nona-4,6-diene tert-butyl (2R)-2-[(7aS)-2(6H)-oxo-7,7a-dihydro-7a-benzofuranyl]piperidine-1-carboxylate tert-butyl (2R)-2-[(2S)-2-[(Z)-4-iodo-3-butenyl]-5(2H)-oxo-2-furyl]piperidine-1-carboxylate(2β,15α)-14,15-dihydro-15-(4-phenylpiperazin-1-yl)securinan-11-one (2β,15α)-14,15-dihydro-15-[4-(4-methoxyphenyl)piperazin-1-yl]securinan-11-one

1(S)-[1'-Tert-Butoxycarbonyl-2'(R)-Piperidinyl]-3-Bromo-9-Oxa-8-Oxobicyclo[4.3.0]Nona-4,6-Diene置于三氟乙酸,Potassium Carbonate体系中,用 四氢呋喃 作为反应溶剂,化学反应 12.25H,以87%的收率获得产物一叶秋碱
参考文献:First Diastereoselective Chiral Synthesis Of (−)-Securinine
标题:First Diastereoselective Chiral Synthesis Of (−)-Securinine
摘要:A Diastereoselective Total Synthesis Of Securinine In Optically Pure Form Was Achieved By Employing Ring-Closing Metathesis Of The Corresponding Dienyne Compound As A Key Step.
DOI:10.1021/ol0361251

专利信息

专利号:US-7829124-B2
优先权日:2001-04-26
标题:Use of Phyllanthus constituents for treating or preventing infections caused by hepatitis B-viruses
发明人：OTT MICHAEL; MANNS MICHAEL P
权利人:OTT MICHAEL; MANNS MICHAEL P
摘要:The disclosure relates to a method of inhibiting synthesis of viral DNA in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting hepatitis B viral DNA synthesis in the mammal using the Phyllanthus component or substance. The disclosure also relates to a method of inhibiting viral gene expression in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting expression of at least one hepatitis B viral gene in the mammal using the Phyllanthus component or substance. These methods may form part of a method of preventing or treating hepatitis B infection.