溶剂黄146置于氯,三氯化磷体系中,化学反应生成 三氯乙酸乙酯 参考文献:Process For Preparing A Mixture Of Trichloroacetic Derivatives And Reaction Products Thereof 标题:Process For Preparing A Mixture Of Trichloroacetic Derivatives And Reaction Products Thereof
专利号:WO-2014166885-A1 优先权日:2013-04-11 标 题:Process for the synthesis of carboxamides 发明人:RODEFELD LARS; SEVERINS CHRISTIAN; HAMMERER TIM; TSICHLA ANGELIKI 权利人:BAYER CROPSCIENCE AG 摘要:The invention provides a process for the synthesis of carboxamides, comprising the steps: a) provision of a carboxylic acid ester of the formula RCOOR' and ammonia (NH 3 ), b) mixing of the carboxylic acid ester of the formula RCOOR' and of ammonia (NH 3 ), and c) reaction of the carboxylic acid ester of the formula RCOOR' and of ammonia (NH 3 ) to give a carboxamide of the formula RCONH 2 and R'OH, characterized in that the ammonia in step a) is introduced in liquid form or in supercritical form. The invention further provides a plant for carrying out the process according to the invention.
专利号:US-2013165350-A1 优先权日:2011-12-22 标 题:Surface linkers for array synthesis 发明人:KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR 权利人:KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR; AFFYMETRIX INC 摘要:The present invention provide several methods of derivatizing a surface of a support with one or more linkers thus providing a suitable platform for synthesis of a polymer array, particular a nucleic acid array. Some methods derivatize a surface with a self-assembled monolayer (SAM) of a linker. The SAM confers advantages of hydrolytic stability, broad compatibility with synthesis and detection chemistries, and reduced emergence of latent functional groups during polymer array synthesis. Substrates can also be derivatized with multi-layers of SAMs providing greater hydrolytic stability. Substrates can also be derivatized by synthesizing a linker in situ on the substrate by atom transfer radical polymerization of functional and functional monomers. Appropriate selection of monomers reduces emergence of latent functional groups in subsequent array synthesis.
专利号:US-5194602-A 优先权日:1988-04-08 标题 :9α-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids 发明人:BATISI JACOBUS N M; MARX ARTHUR F 权利人:GIST BROCADES NV 摘要:New 9α-hydroxy-17-methylene steroids are prepared by the introduction of a substituted 17-methylene group in 9α-hydroxyandrost-4-ene-3, 17-dione. n The resulting compounds are useful starting compounds in the synthesis of corticosteroids.
专利号:US-5578540-A 优先权日:1993-12-17 标题 :Catalyst for the preparation of elastomeric ethylene-propylene copolymers 发明人:BANZI VIVIANO; LOBERTI GIANNI 权利人:ENICHEM ELASTOMERS 摘要:Solid component of a catalyst for the synthesis of elastomeric Ethylene-Propylene copolymers typically amorphous, basically consisting of a Titanium compound supported on a solid component mainly consisting of MgCl 2 , prepared by a process which comprises putting a solution (I), basically consisting of an organometallic compound of Aluminium diluted with aliphatic hydrocarbons, in contact with a solution (II) containing n an anhydrous Magnesium halide in a composition of solvents selected from halohydrocarbons and aromatic hydrocarbons and relative mixtures, in the presence of an Aluminium trihalide; n a tetravalent Titanium compound having general formula Ti(OR) 4-n X n .
专利号:RU-2177955-C2 优先权日:1996-02-16 标 题 :Vanadium compounds, method of their synthesis, method of synthesis of elastomeric copolymers
专利号:US-4668437-A 优先权日:1984-09-12 标 题:Novel 20 benzcylamino pregnene derivatives and process for preparing same 发明人:SOLYOM SANDOR; TOLDY LAJOS; SZILAGYI NEE FARAGO KATALIN 权利人:RICHTER GEDEON VEGYESZET 摘要:The invention relates to new pregnene derivatives of the general formula (I), ##STR1## wherein R 1 stands for a C 1-4 alkyl group; n R 2 stands for a hydrogen atom or a C 2-4 alkanoyl group; n R 3 stands for a hydrogen atom, a hydroxyl group or a C 2-4 alkanoyloxy group; n A represents a ring of the general formula (1) ##STR2## or a ring of the general formula (2), ##STR3## wherein R 4 means a hydrogen atom or a methyl group; n R 5 stands for a hydroxyl group, a C 2-4 alkanoyloxy group or a C 1-3 alkoxy group; n R 6 means a hydroxyl group, a C 2-4 alkanoyloxy group, a C 1-3 alkoxy group, an oxo group or a C 2-3 alkylenedithio group; n the dotted line optionally represents one or more additional valence bonds, with the proviso that, when the dotted line between C 9 and C 11 represents an additional valence bond, then R 3 stands for a hydrogen atom; and the wavy line shows that the given substituent can be bound to the carbon atom in two alternative spatial arrangements, n as well as to their stereoisomers and the mixture of these stereoisomers. n The compounds of the general formula (I) are valuable intermediates for the synthesis of known biologically active 21-hydroxyprogesterone derivatives.
[参考文献]: Mariano A Fernández-Zúmel, Et Al. Atom-Transfer Radical Addition Reactions Catalyzed By Rucp* Complexes: A Mechanistic Study. Chemistry. 2009 Nov 2;15(43):11601-7.
合成参考文献
摘要:March, T. L.; Duggan, P. J., Science of Synthesis Knowledge Updates, (2014) 1, 389. 摘要:Cheng, Q.; Shen, X., Science of Synthesis: Knowledge Updates, (2025) 2.