CAS: 50782-69-9; Vx.

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    专利号:US-12392085-B2
    优先权日:2020-04-28
    标题 :Use of in-situ ionic liquid (IL) and deep eutectic solvent (DES) synthesis using chemically synthesized or biomass-derived ions in the pretreatment of biomass
    发明人:MAGURUDENIYA HARSHA D; ACHINIVU EZINNE; SIMMONS BLAKE A; GLADDEN JOHN M
    权利人:UNIV CALIFORNIA; NATIONAL TECH AND ENGINEERING SOLUTIONS OF SANDIA LLC; NAT TECH & ENG SOLUTIONS SANDIA LLC
    摘要:The present invention provides for a method to deconstruct a biomass comprising: (a) introducing one or more individual components of an ionic liquid (IL) or deep eutectic solvent (DES) to a biomass, wherein the one or more individual components, and optionally any components already present in the biomass, form an IL or DES, or mixture thereof, which solubilizes the biomass to form a solubilized biomass mixture, wherein at least one individual component is introduced to the biomass separately from any other individual component; (b) optionally introducing an enzyme and/or a microbe to the solubilized biomass mixture such that the enzyme and/or microbe produces a sugar from the solubilized biomass mixture; and, (c) optionally separating the sugar from the solubilized biomass mixture.

    专利号:US-10717713-B2
    优先权日:2016-03-02
    标 题 :Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds
    发明人:VALDEZ CARLOS A; LAU EDMOND Y; MAYER BRIAN P
    权利人:L LIVERMORE NAT SECURITY LLC
    摘要:Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable techniques and materials for the synthesis and utilization thereof. In particular various synthetic schemes and techniques for applying the disclosed compositions of matter as a decontaminating agent. The decontaminating agents include homopiperazine-based ligand-metal complexes that are particularly effective at neutralizing toxicity of nerve agents, pesticides, and other toxic organophosphorus-based compounds. In preferred approaches, the homopiperazine-based ligand-metal complexes act as catalysts to facilitate substitution of a leaving group of the organophosphorus-based compound with a functional group that does not permit the organophosphorus-based compound to inactivate acetylcholinesterase upon introduction of the organophosphorus-based compound to a living organism such as insects and mammals. Advantageously, the catalytic homopiperazine-based ligand-metal complexes are formed using inexpensive, readily-available precursor materials, and may be utilized to neutralize toxins without relying on damaging caustic reactants or environmentally unfriendly organic solvents.

    专利号:US-2025075238-A1
    优先权日:2022-01-07
    标 题:Biosynthesis of hierarchical metal organic framework-bacterial cellulose composites
    发明人:FARHA OMAR K; XIN JOHN; MA KAIKAI; CHEUNG YUK HA
    权利人:UNIV NORTHWESTERN; UNIV HONG KONG POLYTECHNIC
    摘要:Composites of metal-organic framework particles and bacterial cellulose, methods of making the composites, and methods of using the composites in the hydrolysis of organic compounds are provided. The composites, which are aerogels comprising metal-organic framework particles embedded in a bacterial cellulose nanofiber network, are fabricated using a microbial synthesis strategy in which bacterial cellulose nanofiber is biosynthesized using a cellulose-producing bacteria in a fermentation medium in which metal-organic framework particles are dispersed.

    专利号:US-6277489-B1
    优先权日:1998-12-04
    标题:Support for high performance affinity chromatography and other uses
    发明人:ABBOTT NICHOLAS; STROEVE PIETER; DUBROVSKY TIMOTHY B; HOU ZHIZHONG
    权利人:UNIV CALIFORNIA
    摘要:Multilayered particulate materials are formed by coating a particulate substrate with a metal and adsorbing an organic layer comprising a recognition moiety onto the metal film. The recognition moiety interacts with an analyte of interest allowing for its detection, purification, etc. Suitable recognition moieties can be selected from a range of species including, small molecules, polymers and biomolecules and the like. The novel particulate materials of the invention can be utilized in an array of methods including, ion-exchange, ion-selective ion-exchange, assays, affinity dialysis, size exclusion dialysis, as supports in solid phase synthesis, combinatorial synthesis and screening of compound libraries and the like.

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    主要参考文献


    1: Langston JL, Myers TM. VX toxicity in the Göttingen minipig. Toxicol Lett. 2016 Dec 15;264:12-19. doi: 10.1016/j.toxlet.2016.10.011. Epub 2016 Oct 20. 42(5):293-299. doi: 10.1093/jat/bkx066.
    53:121-125. doi: 10.1016/j.tiv.2018.08.003. Epub 2018 Aug 9. 2020 Jan–.
    136:24-31. doi: 10.1016/j.bcp.2017.03.020. Epub 2017 Mar 31. 44(8-9):379-396. doi: 10.1080/01902148.2018.1519003. Epub 2019 Feb 22.

    合成参考文献


    摘要:Journal of Toxicology and Environmental Health., 23(103), 1988 []
    摘要:Journal of Pharmacy and Pharmacology., 29(574), 1977 []
    摘要:World Health Organization, Technical Report Series., -(24), 1970
    摘要:Toxicology and Applied Pharmacology., 27(241), 1974 []
    摘要:Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents, National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85, 1(E1), 1982
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