CAS: 49757-42-8; 4,4',4''-(Chloromethanetriyl)Tris(Methoxybenzene)

该化合物是保护在寡甲二烯酸和聚二烯合成中广泛使用的试剂的关键,其主要优势在于它与氢氧基组有选择性的再活动,在固相合成期间能够有效保护核氢氧化锡化物中的5'-氢氧.三氯代苯与母三氯氯甲烷相比,可提高有机溶解性,便于处理和反应控制.TMTr-Cl 的酸性能提高了,允许有温的除腐蚀性条件,最大限度地减少侧面反应.在标准储存条件下的稳定性确保了可靠的时间性能.该化合物由于具有持续的再活动性和与普通磷化学议定书的兼容性,在自动合成中特别有用.

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CAS号3010-81-9 4,4',4''-三甲氧基三苯甲基醇 | CAS号104-92-7 对溴苯甲醚 | CAS号90-96-0 4,4'-二甲氧基二苯甲酮 | CAS号94-30-4 4-甲氧基苯甲酸乙酯 | CAS号13139-86-1 4-甲氧基苯基溴化镁 | CAS号75-36-5 乙酰氯 | CAS号3010-81-9 4,4',4''-三甲氧基三苯甲基醇 | CAS号2132-80-1 4,4-二甲氧基联苯 | CAS号7511-68-4 1-[bis(4-methox... | CAS号90173-60-7 tris(4-methoxyp...

合成工艺路线路线简述

    📜茴香酸乙酯 反应生成 4,4',4'-三甲氧基苯甲基氯
    参考文献:Spectral Detection Of A Transient Ion Pair Intermediate In The Reaction Of A Triarylmethyl Chloride With Pyrrole In Benzene Solution1,2
    标题:Spectral Detection Of A Transient Ion Pair Intermediate In The Reaction Of A Triarylmethyl Chloride With Pyrrole In Benzene Solution1,2
    摘要:
    DOI:10.1021/ja01622A080

    海关参考信息

    专利信息


    专利号:US-4800166-A
    优先权日:1985-04-19
    标题:Method and apparatus for monitoring the automated synthesis of peptides
    发明人:HORN MARCUS J; RECCHIA JOANNE
    权利人:APPLIED PROTEIN TECHNOLOGIES
    摘要:A method for monitoring a solid-phase peptide synthesis for free amino ends of unreacted peptide chains, the monitoring occurring at the end of each addition of a blocked amino acid to the peptide chains which are anchored to the solid phase. The method includes reacting the solid phase with a monitoring agent that forms a covalent bond with unblocked amino groups. The solid phase is then washed to remove the unreacted monitoring agent. A cleaving reagent is then used to selectively remove the covalently bound monitoring reagent from the ends of the unblocked peptide chains, while leaving the blocked chains intact. The amount of monitoring agent thus removed is then quantitatively measured to determine what proportion of the initial peptide chains failed to react with the blocked amino acid. Preferred monitoring agents for use in this process include trityl (triphenylmethyl) -based groups, and particularly preferred agents are trityl, monomethoxytrityl, dimethoxytrityl, and trimethoxytrityl chlorides.

    专利号:US-5817786-A
    优先权日:1983-02-22
    标题 :Single-stranded labelled oligonucleotides of preselected sequences
    发明人:RUTH JERRY L
    权利人:MOLECULAR BIOSYSTEMS INC
    摘要:Substantially pure single-stranded oligonucleotides having a preselected sequence of not more than about 200 nucleotides, at least one of which is at a preselected position in the sequence and includes a base with a covalently attached linker arm containing or capable of binding at least one reporter group or solid support. A process for the chemical synthesis of the substantially pure single-stranded oligonucleotide and modified nucleosides useful in such synthesis are provided.

    专利号:US-6790946-B2
    优先权日:1997-05-14
    标题 :Synthesis of oligonucleotides
    发明人:KWIATKOWSKI MAREK; LANDEGREN ULF; NILSSON MATS
    权利人:QUIATECH AB
    摘要:A method of preparing an immobilized oligonucleotide having a free 3′-end comprises the steps of: i) preparing an oligonucleotide attached in a first position to a solid support via its 3′-end and having a free 5′-end; ii) binding said oligonucleotide in a second position remote from the 3′-end to the solid support; and iii) selectively releasing the 3′-end of the oligonucleotide from the solid support to obta the oligonucleotide attached to the support in said second position in a reversed orientation with a free 3′-end.

    专利号:US-2002051994-A1
    优先权日:1997-05-14
    标题 :Synthesis of oligonucleotides

    专利号:US-2010010069-A1
    优先权日:2006-03-10
    标题 :Extended Length Borane Phosphonate Nucleic Acid Compounds
    发明人:MCCUEN HEATHER BRUMMEL; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H
    权利人:UNIV COLORODO
    摘要:The present invention provides a novel method for solid-phase phosphoramidite based synthesis of borane phosphonate DNA. Also provided are novel phosphoramidite molecules, novel extended length borane phosphonate nucleic acid compounds, and methods of use thereof.

    专利号:US-4701304-A
    优先权日:1985-04-19
    标 题 :Apparatus for automated synthesis of peptides

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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