专利号:WO-2013091696-A1 优先权日:2011-12-21 标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof 发明人:HUMLJAN JAN; MARAS NENAD 权利人:LEK PHARMACEUTICALS; HUMLJAN JAN; MARAS NENAD 摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.
专利号:EP-2468735-A1 优先权日:2010-12-23 标 题:Synthesis of intermediates for preparing anacetrapib and derivates thereof 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.
专利号:US-9862745-B2 优先权日:2004-03-30 标题 :Synthesis of boronic ester and acid compounds 发明人:AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER 权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC 摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
专利号:US-4033949-A 优先权日:1976-04-14 标 题:Analogs of thromboxane B2 and processes for their synthesis 发明人:KELLY ROBERT C; NELSON NORMAN A 权利人:UPJOHN CO 摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-11a-oxa-PGF 2 .sub.α). These analogs are particularly and especially useful as reproductive cycle control agents.
专利号:US-2014046086-A1 优先权日:2012-08-10 标题:Process for the preparation of tafluprost and intermediates thereof 发明人:WEN WEN-HSIEN 权利人:SCINOPHARM CHANGSHU PHARMACEUTICALS LTD 摘要:The present invention provides efficient, economical and environmental friendly methods for synthesis of prostaglandin analogs including tafluprost and intermediates thereof. The invention involves a selective oxidation using in situ boronate ester protection and a unique crystallization method to remove the undesired isomers of fluorinated intermediates.
专利号:WO-2022170218-A1 优先权日:2021-02-05 标题:Intramolecular cyclization for general synthesis of bicyclic alkyl bioisostere boronates 发明人:QIN TIAN; YANG YANGYANG; TSIEN JET 权利人:UNIV TEXAS 摘要:Disclosed herein are methods of synthesizing compounds of the formula (I) wherein the variables are defined herein. Also provided are compounds produced using these methods. In some aspects, the methods provided herein may be used to install aryl bioisosteres.
参考标题:Phosphoric Acid-Catalyzed Asymmetric Synthesis Of Spinol Derivatives 作者:Shaoyu Li,Ji-Wei Zhang,Xian-Lin Li,Dao-Juan Cheng,Bin Tan |发布日期:2016.12.21 摘要:Axially Chiral 1,1'-Spirobiindane-7,7'-Diol (Spinol) Is The Most Fundamental And Important Privileged Structure From Which Other Chiral Ligands Containing A 1,1'-Spirobiindane Backbone Are Synthesized. Driven By The Development Of Enantioselective Syntheses Of Axially Chiral Spinol Derivatives, We Have Successfully Developed The First Phosphoric Acid-Catalyzed Asymmetric Approach. This Approach Is
合成参考文献
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