CAS: 4250-77-5; 6-Hydroxy-2-Phenylchroman-4-One

上下游产品

benzaldehyde 2,5-Dihydroxyacetophenone 2'-hydroxy-5'-(methoxymethoxy)acetophenone 6-hydroxyflavone 3,6-dihydroxyflavone 2-phenyl-chroman-6-ol 2-phenylchroman-4,6-diol 5,6-dihydroxyflavanone

📜黄烷酮置于agrocybe Aegerita Peroxygenase,双氧水,维生素 C体系中,用 水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 8.0H,以33%的收率获得产物6-羟基黄烷酮
参考文献:芳香族过氧化酶对不同类黄酮的区域选择性羟化作用
标题:芳香族过氧化酶对不同类黄酮的区域选择性羟化作用
摘要:芳香过氧化物酶是选择性氧化多种有机化合物的细胞外真菌生物催化剂.我们发现,真菌的过氧柱状田头菇(aae Apo)催化ħ 2 ö 2依赖性多样黄酮的羟基化.反应进行迅速并区域选择性地产生优选的单羟基化产物,例如从黄烷酮,芹菜素,木犀草素,黄酮以及黄豆苷元,槲皮素,山奈酚和染料木黄酮.除了羟化,ø充分甲氧基蜜橘素-Demethylation被催化aaeapo.该酶仅对槲皮素糖苷芦丁缺乏活性,这可能是由于庞大的糖取代基的空间位阻所致.机理研究表明,在羟基化过程中存在环氧化物中间体,并将H2O 2衍生的氧掺入反应产物中.我们的结果提出了真菌过氧合酶可能用于多功能,成本有效且可扩展的类黄酮代谢物合成的可能性.
DOI:10.1016/j.Tet.2011.05.008

专利信息

专利号:US-12194020-B2
优先权日:2017-12-22
标 题:Reversing baldness through cannabinoid receptor activation
发明人：POSTREL RICHARD
权利人:POSTREL RICHARD
摘要:This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.

专利号:US-2013164265-A1
优先权日:2011-12-21
标题 :Skin care compositions
发明人：FLAVIN DANA; OBENLAND SIGRID
权利人:FLAVIN DANA; OBENLAND SIGRID
摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

专利号:US-2014328952-A1
优先权日:2011-12-21
标题:Topical compositions
发明人：FLAVIN DANA
权利人:FLAVIN DANA
摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

专利号:US-8790720-B2
优先权日:2011-12-22
标题:Compositions and methods for treating skin
发明人：RICHARDS JEANETTE ANTHEA; DAWSON THOMAS LARRY; COMBS MARY JANE; DUEVA-KOGANOV OLGA; KOGANOV MICHAEL
权利人:PROCTER & GAMBLE
摘要:The present invention relates to skin care compositions comprising blends of camellia and feverfew serum fractions and/or kelp and parsley serum fractions. The skin care compositions also comprise a dermatologically acceptable carrier. The invention also relates to methods for increasing melanin production in skin by topically applying the skin care composition to areas in order to stimulate one or more steps in melanin synthesis and/or interrupt an inflammatory cycle.