CAS: 41464-41-9; 2,2',5,6'-Tetrachloro-1,1'-Biphenyl
该化合物是多氯联苯(PCB)家族的成员,这些合成有机化学品以其稳定性和耐降解性而著称,该化合物由两个联苯环组成,其中四个氯原子在2,2',5,6和6个位置上被替换,其物理特性包括水中高熔点和低溶解性,使其在环境中具有脂性并具有持久性. 2,2',5,6'-四氯联苯主要用于工业用途,尽管其生产由于环境和健康考虑而基本被禁止或限制,但多氯联苯包括这种化合物已知有毒,有可能对人类健康和野生生物造成有害影响,包括内分泌干扰和致癌性.由于其持久性,它们可以在食物链中积累,从而导致长期的生态影响.已制定管制措施,以监测和管理与此类物质有关的风险,同时强调安全处理和处置做法的重要性.
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- 产品信息参考
;;;; - InChIKey: SFTUSTXGTCCSHX-UHFFFAOYSA-N
- 1S/C12H6Cl4/c13-7-4-5-9(14)8(6-7)12-10(15)2-1-3-11(12)16/h1-6H
- 计算化学: 氢键受体数*氢键供体数*可旋转键数1.0
物理性质
MSDS等安全信息
- GHS符号GHS07
- 警示词Warning
- 危险描述H302-H315-H319-H335
- 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
上下游产品
para-dichlorobenzene 2,6-Dichloroaniline 1,3-dichloro-2-iodobenzene 2,5-dichloroiodobenzene合成工艺路线路线简述
📜1,3-二氯-2-碘苯,1,4-二氯-2-碘苯置于铜体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 2,2',5,6'-四氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4
海关参考信息
- 2903919090-氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:T14: Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
摘要:L4: ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for polychlorinated biphenyls. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L135: International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
摘要:T6: World Health Organization (1993). Environ Health Criteria 140: Polychlorniated Biphenyls and Terphenyls.
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