CAS: 33641-15-5; 1-Methyl-1H-Pyrazol-5-Ol

相似化合物

107296-34-4 5203-77-0 33641-16-6

上下游产品

CAS号34846-90-7 3-甲氧基丙烯酸甲酯 | CAS号60-34-4 甲基肼 | CAS号5788-17-0 3-甲氧基丙烯酸甲酯 | CAS号117007-77-9 5-氯-1-甲基吡唑-4-甲醛 | CAS号91436-74-7 (2-methylpyrazo...

1-甲基-5-羟基吡唑-4-羧酸甲酯置于硫酸体系中,化学反应 8.0H,以18.6 G的收率获得1-甲基-5-羟基吡唑
参考文献:一种吡唑类除草剂中间体1-甲基-5羟基吡唑的制备方法
标题:一种吡唑类除草剂中间体1-甲基-5羟基吡唑的制备方法
摘要:本发明属于吡唑类除草剂中间体制备技术领域,具体涉及一种吡唑类除草剂中间体1‑甲基‑5羟基吡唑的制备方法.所述1‑甲基‑5羟基吡唑的制备方法,包括:(1)在碱存在条件下,化合物(1)丙二酸二甲酯与甲酰胺类化合物,烷基化试剂在溶剂中反应,生成化合物(2);(2)所得化合物(2)与甲基肼/水合肼在溶剂中进行环化反应,再经酸进行水解,脱羧,得到化合物(3).本发明利用dmf,烷基化试剂与化合物(1)反应得到化合物(2);所得化合物(2)在与甲基肼(或水合肼)闭环反应时选择性好,可获得更高收率和纯度的目标产物化合物(3).而且,本发明所述合成方法中使用的原料腐蚀性较弱,易回收,且价格相对低廉,有利于工业化生产.

专利信息

专利号:US-2024409557-A1
优先权日:2023-05-09
标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

专利号:CN-112480008-B
优先权日:2020-12-21
标 题:Synthesis method of 1-methyl-5-hydroxypyrazole

专利号:US-8445510-B2
优先权日:2010-05-14
标题 :Fused bicyclic kinase inhibitors
发明人：MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING
权利人:MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.

专利号:CN-119684211-A
优先权日:2024-12-18
标 题:Synthesis method of compound 4-bromo-5-methoxy-1-methyl-1H-pyrazole

专利号:CN-114436962-A
优先权日:2022-03-09
标 题 :A kind of new synthesis method of oxaflutole impurity

专利号:CN-110105349-A
优先权日:2019-04-29
标 题 :Synthesis method and application of oxaflutole impurity