CAS: 33284-54-7; 2,3,5,6-Tetrachloro-1,1'-Biphenyl
该化合物是一种氯化联苯化合物,其特点是其稳定的芳香结构和高水平卤化度,该化学品由于其持久性和明确化学特性,主要用于研究和工业应用,其四代氯化模式增强了热和化学稳定性,使其成为研究多氯联苯行为的环境和分析化学的有用参考标准.该化合物的低挥发性和降解耐受性使得能够精确地校准色谱分析.然而,由于潜在的毒性和环境持久性,其处理需要严格的安全措施.它不用于商业或消费者用途.
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: BLAYIQLVUNIICD-UHFFFAOYSA-N
- 1S/C12H6Cl4/c13-8-6-9(14)12(16)10(11(8)15)7-4-2-1-3-5-7/h1-6H
- 计算化学: 氢键受体数*氢键供体数*可旋转键数1.0
物理性质
MSDS等安全信息
- GHS符号GHS07
- 警示词Warning
- 危险描述H302-H315-H319-H335
- 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
上下游产品
2,3,5,6-tetrachloroaniline benzene 2,3,4,5,6-pentachlorobiphenyl iodobenzene 1,2,4-trichlorodibenzofuran 2,3,5-trichlorobiphenyl 2,3,6-trichlorobiphenyl合成工艺路线路线简述
📜碘苯,1,2,4,5-四氯苯置于copper(L) Iodide,1,10-菲罗啉,Lithium Tert-Butoxide体系中,用 N,N-二甲基丙烯基脲 用作溶剂,化学反应 12.0H,以74%的收率获得2,3,5,6,-四氯联苯
参考文献:铜催化芳烃 C−h 键芳基化的通用方法
标题:铜催化芳烃 C−h 键芳基化的通用方法
摘要:已经开发出一种铜催化 Pka 低于 35 的 Sp (2) Ch 键芳基化的通用方法.该方法采用芳基卤作为偶联配偶体,锂醇盐或k 3Po 4 碱以及dmf,Dmpu或混合dmf/二甲苯溶剂.多种富电子和缺电子杂环,例如唑类,咖啡因,噻吩,苯并呋喃,氧化吡啶,哒嗪和嘧啶可以芳基化.此外,在苯环上具有至少两个吸电子基团的贫电子芳烃也可以被芳基化.独立合成了两种芳基铜-菲咯啉络合物中间体.
Doi:10.1021/ja805688P
海关参考信息
- 2903911000-邻二氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8952207-B2
优先权日:2007-09-11
标题:Copper-catalyzed C—H bond arylation
发明人：DAUGULIS OLAFS; DO HIEN-QUANG
权利人:DAUGULIS OLAFS; DO HIEN-QUANG; UNIV HOUSTON SYSTEM
摘要:The present invention is a one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using a combination of aryl halides, a substrate, and a copper salt as catalyst. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores and explosives.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Copper-Catalyzed C-H Bond Arylation摘要:The Present Invention Is A One-Step Method For Efficiently Converting Carbon-Hydrogen Bonds Into Carbon-Carbon Bonds Using A Combination Of Aryl Halides, A Substrate, And A Copper Salt As Catalyst. This Method Allows Faster Introduction Of Complex Molecular Entities, A Process That Would Otherwise Require Many More Steps. This Invention Is Particularly Relevant For The Organic Synthesis Of Complex Molecules Such As, But Not Limited To, Pharmacophores And Explosives.
合成参考文献
摘要:T14: Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
摘要:L4: ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for polychlorinated biphenyls. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L135: International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
摘要:T6: World Health Organization (1993). Environ Health Criteria 140: Polychlorniated Biphenyls and Terphenyls.
📝 需求与反馈
尽可能描述清楚需求与问题信息
