CAS: 300-87-8; 3,5-Dimethylisoxazole

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CAS号123-54-6 乙酰丙酮 | CAS号53009-14-6 3,5-dimethyl-4H... | CAS号71989-66-7 1H-Pyrazole,4-b... | CAS号55393-93-6 2-acetyl-3-meth... | CAS号71989-58-7 1-hydroxy-3,5-d... | CAS号21139-18-4 4,6-dimethyl-1-... | CAS号133329-05-2 3,5-dimethyl-4H... | CAS号74152-12-8 4,6-dimethyl-1-... | CAS号2157-56-4 2,4-戊烷二酮二肟 | CAS号49783-72-4 3-甲基异恶唑-5-碳酰氯 | CAS号3405-77-4 5-甲基异噁唑-3-甲酸 | CAS号31329-64-3 4-氨基-3,5-二甲基异恶唑 | CAS号36958-61-9 5-(溴甲基)-3-甲基异恶唑 | CAS号1446418-87-6 2-[5-(3,5-dimet... | CAS号3319-99-1 2-(2-噻吩)吡啶 | CAS号4857-42-5 3-甲基异恶唑-5-甲酸 | CAS号21802-37-9 Caerulomycin A. | CAS号19986-25-5 2-Propanone, 1-... | CAS号67-51-6 3,5-二甲基吡唑

乙酰丙酮置于盐酸羟胺体系中,化学反应生成3,5-二甲基异唑
参考文献:基于苯乙烯基恶唑的荧光探针,用于检测硫化氢
标题:基于苯乙烯基恶唑的荧光探针,用于检测硫化氢
摘要:已经合成了带有与庞大的芳族环连接的硝基的苯乙烯基恶唑,并对其在有机溶剂和水中的吸收和发射研究进行了研究.分子在可见光区显示发射,且受芳香族环的扩展共轭作用和分子内电荷转移的影响,溶剂化显色发射发生明显变化.这些吸收和发射变化用于在硫化钠水溶液存在下通过将硝基还原为胺基来有效和灵敏地检测痕量浓度的硫化氢(h 2 S).实验结果表明,该探针显示出极佳的发射响应,并且发射变化很大,灵敏度为微摩尔检测极限.
Doi:10.1039/c7Pp00331E

专利信息

专利号:US-5679864-A
优先权日:1995-11-03
标题:Process for the synthesis of curcumin-related compounds
发明人：KRACKOV MARK HARRY; BELLIS HAROLD EDWARD
权利人:GENE PRINT INC
摘要:The invention is directed to a process for the synthesis of curcumin and curcumin-related compounds by reacting the enol form of a 2,4-diketone with a monocarbocyclic aldehyde in the presence of an organic amine catalyst. The reactants are dissolved in a highly polar, aprotic organic solvent. The curcumin-related product is recovered in crystalline form by precipitation from the reaction mass and solvent recrystallization.

专利号:US-9802952-B2
优先权日:2013-07-15
标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
发明人：KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY
权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V
摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-8114993-B2
优先权日:2007-02-06
标题:Use of aryl chlorides in palladium-catalyzed C-H bond functionalization
发明人：DAUGULIS OLAFS; CHIONG HENDRICH
权利人:DAUGULIS OLAFS; CHIONG HENDRICH; UNIV HOUSTON SYSTEM
摘要:A one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using chloroarenes and palladium catalysts is disclosed. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores.

专利号:US-4347183-A
优先权日:1981-02-02
标 题 :Process for the synthesis of penems and carbapenems
发明人：AFONSO ADRIANO; HON FRANK
权利人:SCHERING CORP
摘要:Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid halide in the presence of a tertiary amine and an alkaline earth metal carbonate, followed by reaction of the thereby formed 1-imido-4-substituted-azetidine-2-one with a trialkyl phosphite. n Also described are novel penems useful as antibacterials which are prepared by the described process.

专利号:US-9593071-B2
优先权日:2011-11-22
标题 :Process for the preparation of gamma amino acids and intermediates used in said process
发明人：ADAMO MAURO
权利人:ROYAL COLLEGE SURGEONS IRELAND
摘要:The invention relates to the preparation of gamma amino acids of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof, and to intermediates used for their preparation. (formula I) wherein R 1 is selected from an alkyl group, an alkenyl group, an alkynyl group and a cycloalkyl group, each of which may be optionally substituted and * denotes a chiral center. In particular, the present invention provides an efficient synthesis of (S)-pregabalin which is suitable for carrying out on an industrial scale.