CAS: 29700-34-3; L-Phenylalanine-15N

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CAS号114-76-1 苯丙酮酸钠盐

📜(2S,2'S)-N-<2'-<15N>Amino-3'-Phenylpropanoyl>Bornane-10,2-Sultam置于盐酸,Lithium Hydroxide,水体系中,化学反应生成L-苯丙氨酸-15N
参考文献:Stereoselective Synthesis Of Stable Isotope-Labeled L-α-Amino Acids: Electrophilic Amination Of Oppolzer'S Acyl Sultams In The Synthesis Of L-[15N]Alanine,L-[15N]Valine,L-[15N]Leucine,L-[15N]Phenylalanine And L-[1-13C,15N]Valine
标题:Stereoselective Synthesis Of Stable Isotope-Labeled L-α-Amino Acids: Electrophilic Amination Of Oppolzer'S Acyl Sultams In The Synthesis Of L-[15N]Alanine,L-[15N]Valine,L-[15N]Leucine,L-[15N]Phenylalanine And L-[1-13C,15N]Valine
摘要:Using 1-Chloro-1-[n-15]Nitrosocyclohexane,We Have Prepared Five L-[alpha-N-15]Amino Acids. The Stereoselective Electophillic Hydroxyamination Of (S)-Acylbornane-10,2-Sultams,Followed By Zn-O/h+ Reduction,And Alkaline Cleavage Of The Chiral Auxiliary,Gave The Amino Acids In 97.2-99.5% E.E. By Starting With Labeled (S)-Acylbornane-10,2-Sultams This Stereoselective Route Could Be To Prepare Many C-13 And/or N-15 Isotopomers Of Alpha-Amino Acids.
Doi:10.1002/(Sici)1099-1344(199603)38:3<239::Aid-Jlcr831>3.0.Co;2-E