CAS: 24131-31-5; (3,5-Bis(Benzyloxy)Phenyl)Methanol

上下游产品

methyl 3,5-bis(benzyloxy)benzoate 3,5-dibenzyloxybenzoic acid (3,5-di-benzyloxy)benzoic acid benzyl ester 3,5-Dihydroxybenzoic acid (3',5'-dibenzyloxy)phenylacetonitrile 3,5-dibenzyloxybenzaldehyde 2-bromo-1-(hydroxymethyl)-3,5-bis-(benzyloxy)-benzene 3,5-bis(benzyloxy)benzyl bromide

3,5-二羟基苯甲酸置于lithium Aluminium Tetrahydride,硫酸,Potassium Carbonate体系中,用 乙醚,丙酮 用作溶剂,化学反应生成3,5-二苄氧基苯甲醇
参考文献:活性异皂甙元二聚体的仿生合成.
标题:活性异皂甙元二聚体的仿生合成.
摘要:用几种无机试剂和过氧化物酶处理合成的异皂甙元,从而制备出活性的二苯乙烯二聚体.其中,乙酸银在甲醇中,得到了两个新的异丹叶大黄素二聚体4和5,具有四个已知的天然茋二聚体一起2,3,6,和7.在光谱分析的基础上确定了它们的结构和相对构型,并讨论了它们的可能形成机理.化合物2,6,和7的第一次是人工合成的.评价所有产品的抗炎活性.
Doi:10.1080/10286020.2014.913030

专利信息

专利号:WO-0160774-A1
优先权日:2000-02-16
标题 :Synthesis of resveratrol
发明人：ANDRUS MERRITT; MEREDITH ERIK
权利人:UNIV BRIGHAM YOUNG; ANDRUS MERRITT; MEREDITH ERIK
摘要:The invention relates to novel methods of producing resveratrol. Resorcylic acid is reacted with benzyl bromide in acetone under basic conditions to give a protected benzyl ester. Treatment with KOH allows for removal of the potassium benzoate from the benzyl alcohol by-product. Acidification followed by LAH reduction gives a benzyl alcohol in high overall yield. The benzyl alcohol is converted to a bromide using phosphorus tribromide. An Arbuzov reaction is then conducted using isopropyl phosphite to give the corresponding phosphonate in high yield. Coupling with 4-benzyloxybenzaldehyde at 1:1 stoichiometry with sodium methoxide gave the E-stilbene as a single isomer in good yield. An alternative method involves a palladium catalysis. 3,5-substituted benzoic acid chlorides react with acetoxy styrene using catalytic amounts of palladium acetate and trialkylamine to give stilbene products.

专利号:GB-2450682-A
优先权日:2007-06-26
标题 :Use of benzyl protection in the synthesis of 5-n-alkylresorcinols

专利号:KR-20100009664-A
优先权日:2008-07-21
标 题 :Improved Synthesis of PIC-eAtantione using a Trans-Selective Reaction Method

专利号:CN-1065238-C
优先权日:1993-01-29
标题 :Intermediate compounds suitable for the synthesis of modified oligodeoxynucleotides