CAS: 23356-96-9; L-Prolinol

上下游产品

CAS号147-85-3 脯氨酸 | CAS号98-79-3 L-焦谷氨酸 | CAS号854917-80-9 (S)-(1-(4-metho... | CAS号142-47-2 谷氨酸钠 | CAS号62024-36-6 5-chloro-4-oxop... | CAS号171561-60-7 3-(6-oxo-5R-phe... | CAS号105173-13-5 [1-(4-nitrophen... | CAS号460746-46-7 ABT-239 | CAS号108-94-1 环己酮 | CAS号146405-63-2 (S)-(9CI)-1-(二氯... | CAS号51207-66-0 (S)-(+)-1-(2-吡咯... | CAS号186202-18-6 2-Pyrrolidineme... | CAS号183014-03-1 furan-2-yl-[(2S... | CAS号182277-12-9 (2S)-1-(2-azido... | CAS号195443-47-1 [(2S)-1-(4-brom... | CAS号34381-71-0 N-甲基-L-脯氨醇

L-焦谷氨酸置于氢气,溶剂黄146体系中,用 水 用作溶剂,100.0 °C,7.0 Mpa 条件下,反应 20.0H,以95%的收率获得l-脯氨醇
参考文献:一种l-脯氨醇的制备方法
标题:一种l-脯氨醇的制备方法
摘要:本发明涉及一种l‑脯氨醇的制备方法,采用廉价的l‑焦谷氨酸为原料,用过渡金属原子改性的钌碳催化剂催化l‑焦谷氨酸高压加氢还原制备l‑脯氨醇.该改性后的钌碳催化剂催化活性显著高于现有商业钌碳催化剂,可使l‑焦谷氨酸中难以实现的内酰胺加氢反应顺利进行.本发明的l‑脯氨醇的制备方法,工艺路线短,收率高达90%左右,后处理简单,催化剂可套用20次以上,酸水蒸馏后可循环套用,基本做到了绿色合成,没有废水,废渣产生,避免了硼氢化物,氢化铝锂等还原产生大量固废和废水,尤其适合大规模工业化生产.

专利信息

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:WO-2017033128-A1
优先权日:2015-08-25
标题 :Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
发明人：HOOK DAVID; KU JIE; ZHOU JIANGUANG
权利人:NOVARTIS AG; HOOK DAVID; KU JIE; ZHOU JIANGUANG
摘要:The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors and prodrugs thereof.

专利号:EP-1730108-B1
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin d analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.

专利号:EP-1735276-B1
优先权日:2004-04-02
标题:Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues
发明人：HANSEN ERIK TORNGAARD; SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; PEDERSEN HENRIK; DEUSSEN HEINZ-JOSEF WILHELM
权利人:LEO PHARMA AS
摘要:The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

专利号:US-8759555-B2
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin D analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.

专利号:US-6117993-A
优先权日:1995-05-23
标题 :Synthons for oligonucleotide synthesis
发明人：IYER RADHAKRISHNAN P; YU DONG; GUO MAO-JUN; AGRAWAL SUDHIR
权利人:HYBRIDON INC
摘要:The invention provides new reagents and processes for synthesizing oligonucleotides, including stereoselective oligonucleotide synthesis. In a first aspect, the invention provides novel monomer synthons for the synthesis of oligonucleotides. Monomer synthons according to this aspect of the invention are useful in the synthesis of oligonucleotides and can be used in place of the well known beta-cyanoethyl phosphoramidite monomer synthon in the phosphoramidite synthesis procedure. Certain monomer synthons according to this aspect of the invention are useful in this procedure for producing oligonucleotides having defined stereochemistry. n In a second aspect, the invention provides processes for synthesizing monomer synthons according to the invention, including diastereomerically enriched or purified monomer synthons. In the processes according to this aspect of the invention, the chemical reactions are stereoretentive so that the products of each reaction retain the same stereoconfiguration as their precursor reagent. n In a third aspect, the invention provides processes for synthesizing oligonucleotides using the well known phosphoramidite approach. In the processes according to this aspect of the invention, any of the monomer synthons according to the invention is used in place of the conventional beta-cyanoethyl phosphoramidite.