CAS: 1942-45-6; Oct-4-Yne

上下游产品

CAS号698-93-1 2,3-dipropylcyc... | CAS号7321-48-4 4-chloro°Ct-4-ene | CAS号20184-91-2 4-壬炔 | CAS号14850-23-8 反-4-辛烯 | CAS号69298-55-1 4,5-dibromo°Ct-4-ene | CAS号106-94-5 溴代丙烷 | CAS号2586-89-2 3-庚炔 | CAS号1066-26-8 乙炔化钠,二甲苯溶液 | CAS号124471-41-6 4,5-diiodo°Ct-4-ene | CAS号58608-93-8 meso-4,5-dibrom... | CAS号105430-58-8 2,3,4,5-tetrapr... | CAS号2456-68-0 Hexapropylbenzene | CAS号3400-45-1 环戊甲酸 | CAS号77124-21-1 (E)-2-n-Propyl-... | CAS号496-77-5 5-羟基-4-辛酮 | CAS号5455-24-3 4,5-辛二酮 | CAS号5162-93-6 α,β-epoxy-4-°Ctanone | CAS号420-56-4 三甲基氟硅烷 | CAS号32294-60-3 联苯二碲 | CAS号123630-52-4 (E)-4-acetoxy-5...

📜5-羟基-4-辛酮置于一水合硫酸镁,磷酸二苯酯,N,N'-羰基二咪唑体系中,用 2-甲基-2-丁醇 用作溶剂,化学反应 36.0H,反应生成4-辛炔
参考文献:α-羟基酮直接转化为炔烃
标题:α-羟基酮直接转化为炔烃
摘要:炔烃是有机化学中非常重要的官能团,既可以作为目标结构的一部分,也可以作为通用的合成中间体.在这项研究中,报道了将α-羟基酮直接转化为炔烃的方案.结合通过形成中央c-c键生成所需起始原料的多种合成方法,它可实现高度通用的炔烃片段偶联方法.除了机械方面的见解之外,还显示了这种新颖转变的广泛范围.此外,通过将其与各种α-羟基酮合成配合使用,证明了本协议的实用性,从而可以使用各种炔烃.
Doi:10.1021/acs.Joc.8B02941

专利信息

专利号:US-2007049757-A1
优先权日:2005-08-26
标题:Methods for the synthesis of substituted amino uracils
发明人：RIEGER JAYSON M; THOMPSON ROBERT
权利人:RIEGER JAYSON M; THOMPSON ROBERT
摘要:The invention provides novel methods of preparing substituted amino uracil compounds that can be employed as useful intermediates in the synthesis of various xanthines. Highly regioselective unsymmetrical amino uracils can be obtained using these methods which is a particular advantage over other existing methods.

专利号:US-3699146-A
优先权日:1970-03-31
标题:Synthesis of methyl malvalate and methyl 5,6-methano-5-undecenoate
发明人：GENSLER WALTER J
权利人:US AGRICULTURE
摘要:This invention relates to the preparation of methyl malvalate, methyl 5,6-methano-5-undecenoate and the preparation of some new intermediates. Malvalic acid, the major cyclopropene component in cottonseed oil, has been synthesized. When 1-chloro-7-hexadecyne reacts with diazoacetic ester in the presence of copper bronze, the ester of 1-chloro-7,8-carboxymethano-7-hexadecene is formed. Treating the corresponding acid chloride with zinc chloride causes loss of carbon monoxide. Either sodium borohydride or lithium aluminum hydride reduces the resulting cyclopropenium compound to 1-chloro-7,8-methano-7-hexadecene. Replacing the chloro group with cyano yields malvalonitrile, which can be converted to methyl malvalate. An analogous sequence of steps has been applied to 1-chloro-4-decyne to produce methyl 5,6-methano5-undecenoate. An alternate synthesis of methyl malvalate starts by using 1-chloro-7-hexadecyne as the precursor for methyl 8heptadecynoate. This acetylenic ester is converted to 8,9carboxymethano-8-heptadecenoic acid, the diacid chloride of which decarbonylates selectively in the presence of metallic chlorides to form the cyclopropenium-acid chloride. After esterification the resulting cyclopropenium-ester is reduced with borohydride to methyl malvalate.

专利号:US-10538790-B2
优先权日:2016-04-04
标题 :Bioenzymatic synthesis of THC-v, CBV and CBN and their use as therapeutic agents
发明人：KAVARANA MALCOLM J; PEET RICHARD C
权利人:TEEWINOT TECH LIMITED
摘要:The present invention provides methods for producing cannabinoids. More specifically, the invention is directed to the bio-enzymatic synthesis of THC-v, CBV and CBN by contacting a compound according to Formula I with a cannabinoid synthase enzyme. Also described is a system for producing these pharmaceutically important cannabinoids and the use of such cannabinoids as therapeutic agents.

专利号:US-9221821-B2
优先权日:2012-06-05
标题:Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds
发明人：DIEP NHUT; KALYAN YURIY B
权利人:FOREST LAB HOLDINGS LTD; FOREST LAB HOLDINGS LTD
摘要:Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

专利号:US-10829792-B2
优先权日:2017-03-21
标 题 :Biocatalytic synthesis of strained carbocycles
发明人：CHEN KAI; HUANG XIONGYI; KAN S B JENNIFER
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.

专利号:US-2023212216-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
发明人：MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
权利人:GENIE BIOTECH UK LTD
摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.