CAS: 17396-35-9; 4-Tetrahydrothiopyranone 1,1-Dioxide

相似化合物

194152-05-1 99586-63-7 2756575-41-2

上下游产品

CAS号1072-72-6 四氢噻喃-4-酮 | CAS号139-33-3 乙二胺四乙酸二钠 | CAS号4160-61-6 四氢-4-氧代-2H-噻喃-3-甲酸甲酯 | CAS号4131-74-2 3,3'-硫代二丙酸二甲酯 | CAS号111-17-1 3,3'-硫代二丙酸 | CAS号39557-51-2 prop-2-enyl 3-(... | CAS号17396-38-2 4H-Thiopyran-4-... | CAS号408314-20-5 3,5-dibromo-1,1... | CAS号16841-46-6 3,6-dihydro-2H-... | CAS号4988-33-4 Pentamethylene ... | CAS号210240-20-3 4-氨基四氢-2H-噻喃1,1-二氧化物 | CAS号194152-05-1 四氢-2h-硫代吡喃-4-醇 ... | CAS号62826-67-9 1-oxa-6$l^{6}-t... | CAS号38690-86-7 4-Acetoxy-thiac...

四氢噻喃-4-酮置于间氯过氧苯甲酸体系中,用 氘代氯仿 用作溶剂,化学反应生成四氢噻喃-4-酮 1,1-二氧化物
参考文献:观察并计算了模型硫化物就地氧化为亚砜和砜所引起的1H和13C化学位移.
标题:观察并计算了模型硫化物就地氧化为亚砜和砜所引起的1H和13C化学位移.
摘要:通过在氘代氯仿中逐步添加间氯过苯甲酸,在NMR样品管中将一系列模型硫化物氧化为亚砜和砜.已经测试了多种量子化学计算方法,以再现观测到的起始硫化物及其氧化产物的(1)h和(13)c化学位移.已经表明,确定能量最小的构象是在随后的NMR化学位移计算中获得实际数据的非常重要的条件.对于碳原子(甚至对于"便宜"的dft B3Lyp / 6-31G *方法),计算得出的化学位移与观测到的化学位移之间的相关性非常好,而对于氢原子则不太令人满意.
Doi:10.1002/mrc.2658

专利信息

专利号:US-6951878-B2
优先权日:1998-03-12
标 题:Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)
发明人：MOELLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILLIAM CHARLES; GE YU; UYEDA ROY TERUYUKI
权利人:NOVO NORDISK AS
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2025276972-A1
优先权日:2020-12-15
标 题:Compounds as casein kinase inhibitors
发明人：Zhou Enxing; LIU YUAN; WANG HANPING; WU GUANGLONG; SHAO NING
权利人:GRITSCIENCE BIOPHARMACEUTICALS CO LTD
摘要:Provided are casein kinase inhibitors, or pharmaceutically acceptable salts thereof. Corresponding pharmaceutical compositions, methods of synthesis, and intermediates are also provided.

专利号:CN-111349061-A
优先权日:2018-12-21
标题:Synthesis method of tetrahydrothiopyran-4-one 1,1-dioxide

专利号:CN-111349061-B
优先权日:2018-12-21
标 题:Synthesis method of tetrahydrothiopyran-4-one 1,1-dioxide