CAS: 135544-68-2; N-(Allyloxycarbonyloxy)Succinimide

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477775-77-2 66065-85-8 13139-12-3

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CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号2937-50-0 氯甲酸烯丙酯 | CAS号1007859-08-6 4-(羟基甲基)苄基氨基甲酸烯丙酯 | CAS号178481-32-8 6-(prop-2-enoxy...

📜N,N'-二琥珀酰亚胺基碳酸酯,烯丙醇置于三乙胺体系中,用 乙腈 用作溶剂,化学反应 20.0H,以57%的收率获得烯丙基琥珀酰亚胺基碳酸酯
参考文献:末端烯烃作为代谢寡糖工程的多功能化学报告基团
标题:末端烯烃作为代谢寡糖工程的多功能化学报告基团
摘要:具有反电子需求的diels-Alder反应(dainv反应)与1,2,4,5-四嗪与富电子或紧张烯烃的反应,被证明是一种生物正交的连接反应,反应速度快且收率高.Dainv反应的重要应用是代谢寡糖工程(moe),它可以使活细胞中的糖缀合物可视化.在这种方法中,将带有化学报告基团的糖衍生物代谢结合到细胞糖缀合物中,随后通过生物正交连接反应用探针衍生.在这里,我们研究了一系列新的甘露糖胺和葡糖胺衍生物,这些衍生物具有不同长度的氨基甲酸酯连接的侧链,这些侧链被烯烃基团封端,并且适合于标记细胞表面聚糖.动力学研究表明,Dainv反应中烯烃的反应性随链长的增加而增加.当应用于moe时,其中一种化合物会被过乙酰化n-丁烯氧基羰基甘露糖胺特别适合于标记细胞表面聚糖.显然,其侧链的长度代表掺入效率和标记反应速度之间的最佳平衡.在生物正交标记反应之前对细胞的唾液酸酶处理显示该糖衍生物以相应的唾液酸衍生物的形式
Doi:10.1002/chem.201404716

专利信息

专利号:US-2010197891-A1
优先权日:2006-10-05
标题:Method for peptide synthesis
发明人：GIRAUD MATTHIEU; ALBERICIO FERNANDO; QUATTRINI FRANCESCA; WERBITZKY OLEG; SENN KATJA; WILLINER MICHAELA
权利人:GIRAUD MATTHIEU; ALBERICIO FERNANDO; QUATTRINI FRANCESCA; WERBITZKY OLEG; SENN KATJA; WILLINER MICHAELA
摘要:A new method of anchoring a growing peptide chain during chemical synthesis to a solid-phase support is devised. Novel amino acid derivatives and peptide derivatives, both unbonded and bonded to a solid-phase support, are also provided.

专利号:US-11161869-B2
优先权日:2017-04-12
标 题:Thermally-cleavable protecting and linker groups
发明人：CROSBY STUART RICHARD; JENNISON MATHEW; BRENNAN JOSEPH
权利人:EVONETIX LTD
摘要:The present invention relates to chemical linkers and protecting groups, compounds and compositions containing the chemical linkers or protecting groups, and intermediates and processes that can be used to prepare them. The chemical linkers and protecting groups are based on pyrrolidine and piperidine activating groups, which undergo intramolecular cyclisation upon heating with release of carbon dioxide, thereby releasing the organic compound from a substrate. In particular, those chemical linkers and protecting groups are useful in the solid phase synthesis of oligonucleotides according to the following representative schemes.

专利号:US-2024197726-A1
优先权日:2021-03-03
标 题:Novel tetrahydroisoquinoline alkaloid compound containing macrocycle
发明人：OGURI HIROKI; TANIFUJI RYO
权利人:UNIV TOKYO
摘要:[Problem] To provide: a novel tetrahydroisoquinoline (THIQ) alkaloid compound having a macrocyclic structure; an intermediate of the compound; and a method for producing the compound.[Solution] Provided is a compound represented by formula (I), or a pharmaceutically acceptable salt thereof.The present invention also provides: a method for synthesizing this compound; and an intermediate compound useful in this synthesis.

专利号:TW-200831527-A
优先权日:2006-10-05
标题:Method of peptide synthesis