CAS: 13290-74-9; 1-Chloro-2-Methyl-4-Nitrobenzene

相似化合物

7149-75-9 51719-46-1 16588-02-6

上下游产品

CAS号638-03-9 间甲苯胺盐酸盐 | CAS号95-49-8 邻氯甲苯 | CAS号99-52-5 2-甲基-4-硝基苯胺 | CAS号7697-37-2 硝酸 | CAS号110-86-1 吡啶 | CAS号420134-77-6 2-chloro-5-nitr... | CAS号64-17-5 乙醇 | CAS号51123-59-2 2-氨基-6-氯-3-硝基甲苯 | CAS号34662-36-7 3-氯-5-硝基苯甲酸 | CAS号383432-38-0 2-甲氧基-N-[(2E)-3... | CAS号50741-92-9 2-甲氧基-5-硝基苯甲醚 | CAS号455-88-9 2-氟-5-硝基甲苯 | CAS号30273-23-5 4-氯-3-甲基苯胺盐酸盐 | CAS号108-44-1 3-甲基苯胺 | CAS号7149-75-9 4-氯-3-甲基苯胺 | CAS号89-54-3 5-氨基-2-氯苯甲酸 | CAS号52427-01-7 2-(溴甲基)-1-氯-4-硝基苯 | CAS号116632-41-8 2-氯-5-碘甲苯

3-硝基甲苯置于氯,铁粉体系中,化学反应 6.0H,以90%的收率获得2-氯-5-硝基甲苯
参考文献:一种2-氯-5-硝基-甲苯的制备方法
标题:一种2-氯-5-硝基-甲苯的制备方法
摘要:本发明涉及精细化工中间体的制备,具体的说是一种2‑氯‑5‑硝基‑甲苯的制备方法.以氯气作为氯化试剂,过渡金属或其相应的盐作为催化剂,对原料间硝基甲苯进行催化氯化制备获得2‑氯‑5‑硝基‑甲苯.本发明以氯气作为氯化试剂,采用过渡金属或其相应的盐进行间硝基甲苯的催化氯化,可实现苯环上的高转化率,高选择性氯化,要高于重氮化氯化工艺和硝化工艺85%的选择性.工艺简单易行,适合工业化生产,而且所用原料价格低廉,工艺成本低,具有较高的经济价值.本发明废水量少,解决了重氮化氯化法和硝化法制备2‑氯‑5‑硝基‑甲苯工艺产生的大量含酸废水的环保问题,具有较高的环保价值.

专利信息

专利号:US-6159673-A
优先权日:1996-07-17
标 题:Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound
发明人：NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M is a cation. Other oxonol compounds, a light-sensitive material containing an oxonol compound and a process for the synthesis of an oxonol compound are also disclosed.

专利号:US-6828466-B2
优先权日:2002-07-19
标题:Process for the synthesis of phenols from arenes
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
权利人:UNIV MICHIGAN STATE
摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

专利号:US-7718598-B1
优先权日:1998-09-25
标 题:Auxiliary for amide bond formation
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programmes. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganizing peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-5786448-A
优先权日:1996-11-07
标题:Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
发明人：NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.

专利号:US-6809202-B2
优先权日:1996-11-07
标 题 :Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
发明人：NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl gorup and 6-8 atoms in the ring is disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-2004030197-A1
优先权日:2002-07-19
标 题 :Process for the synthesis of phenols from arenes