CAS: 13211-31-9; (S)-Tert-Butyl 2-Amino-3-Methylbutanoate

相似化合物

13518-40-6 6070-59-3 104944-18-5

上下游产品

CAS号540-88-5 醋酸叔丁酯 | CAS号72-18-4 l-缬氨酸 | CAS号1149-26-4 CBZ-L-缬氨酸 | CAS号13518-40-6 L-缬氨酸叔丁酯盐酸盐 | CAS号115-11-7 2-甲基丙烯 | CAS号349-00-8 N-(2,2,2-三氟乙酰基)... | CAS号192725-86-3 N-(3-甲氧基-3-羰基丙基... | CAS号21285-27-8 L-Valine,1-[(ph... | CAS号192725-87-4 N-(3-丙酰氨基)-L-缬氨... | CAS号86895-14-9 N-Fm°C-甘氨酰缬氨酸 | CAS号13123-00-7 Z-Phe-Val-OH | CAS号1149-26-4 CBZ-L-缬氨酸 | CAS号192725-39-6 Lopinavir Metab...

📜N-Trifluoroacetyl-L-Valine置于sodium Hydroxide,硫酸体系中,用 1,4-二氧六环 用作溶剂,化学反应 2.0H,反应生成L-缬氨酸叔丁酯盐酸盐
参考文献:高效(约40克)实验室规模制备(S)-和(R)-缬氨酸叔丁酯
标题:高效(约40克)实验室规模制备(S)-和(R)-缬氨酸叔丁酯
摘要:已经开发了用于制备对映体纯的(S)-和(R)-缬氨酸叔丁酯的大实验室规模(约40G)的方法.该方法包括三个步骤:制备n-Tfa-缬氨酸,在硫酸存在下使用2-甲基丙烯在二恶烷中制备缬氨酸叔丁酯,以及分离目标化合物作为乙酸酯衍生物.相对于起始缬氨酸,总产率高达70%,Ee大于98%(通过HPLC).
Doi:10.1016/s0957-4166(02)00532-3

专利信息

专利号:US-2010022767-A1
优先权日:2008-07-25
标题 :Development of a synthesis of syringolin a and b and derivatives thereof
发明人：KAISER MARKUS; CLERC JEROME
权利人:MAX PLANCK GESELLSCHAFT
摘要:The synthesis of syringolin A and B and derivatives thereof as well as to pharmaceutical compositions containing the syringolin A or B or derivatives thereof and the use of syringolin A and B and derivatives thereof for prophylaxis and treatment of cancer.

专利号:US-5280093-A
优先权日:1989-06-29
标题 :Chiral polymers for the synthesis of pure enantiomers of amino acids
发明人：JACQUIER ROBERT; CALMES MONIQUE; DAUNIS JACQUES
权利人:RHONE POULENC CHIMIE
摘要:The present invention relates to chiral polymers and to their uses for operations of asymmetric synthesis, deracemization and optical inversion. n These polymers are characterized in that they comprise: n a chiral unit n a functionalizing unit n an optional crosslinking unit n Application to chiral organic synthesis.

专利号:US-6867202-B1
优先权日:1997-06-25
标 题 :Treatment of insulin resistance
发明人：CARPINO PHILIP ALBERT; CHIU CHARLES KWOK-FUNG; PAN LYDIA CODETTA; LEFKER BRUCE ALLEN; TREADWAY JUDITH LEE; ZAWISTOSKI MICHAEL PAUL
权利人:PFIZER
摘要:This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, n n nwhere the variables are defined in the specification, or the stereoisomeric mixtures, diastereomerically enriched, diastereomerically pure, enantiomerically enriched or enantiomerically pure isomers, or the pharmaceutically acceptable salts and prodrugs thereof to said mammal. The compounds of formula I are growth hormone secretagogues and as such are useful for increasing the level of endogenous growth hormone. In another aspect this invention provides certain intermediates which are useful in the synthesis of the foregoing compounds and certain processes useful for the synthesis of said intermediates and th compounds of formula I. This invention is further directed to methods comprising administering to a human or other animal a combination of a functional somatostatin antagonist such as an alpha-2 adrenergic agonist and a compound of formula I.

专利号:WO-2024075813-A1
优先权日:2022-10-07
标 题:Polypeptide synthesis using diketopiperazine compound
发明人：YAMAMOTO HISASHI; MITSUDA MASARU; HATTORI TOMOHIRO
权利人:CHUBU UNIV EDUCATIONAL FOUNDATION
摘要:Provided are: a novel diketopiperazine compound for rapid and easy synthesis of various polypeptides; and a method for manufacturing the same. The diketopiperazine compound is represented by general formula (1). (In the formula, R 1 , R 2 , R 3 , R 4 , and R 5 are each independently a hydrogen atom, a substituted or unsubstituted hydrocarbon group, or a substituted or unsubstituted heterocyclic group. R 1 and R 2 , R 1 and R 5 , R 2 and R 5 , and/or R 3 and R 4 are each optionally bonded to form a ring. PGE represents an electron-withdrawing protective group.)

专利号:US-4111933-A
优先权日:1976-04-30
标题:Protection of functional groups during reaction and their subsequent restoration
发明人：ECKERT HEINER; UGI IVAR; KABBE HANS-JOACHIM
权利人:BAYER AG
摘要:In the process for preparing an organic compound of the formula n n A' -- X n n in which n X is an amino group, a hydroxyl group or a carboxyl group, and n A' is the remainder of the molecule, from an organic compound of the formula n n A -- X n n in which n A is the remainder of the molecule which can undergo reaction to form A', by converting A -- X into a compound of the formula n n A -- Z -- COOR n n in which n Z is --NH--, --O-- or a direct C--C bond, and n R is a radical of the formula ##STR1## IN WHICH Y is a direct C--C single bond, the --CHâ•?CH-- group or an arylene group, n R 1 to R 4 each independently is hydrogen, halogen or an alkyl, aryl, aralkyl, alkoxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl or cycloalkylaminocarbonyl radical, or n R 1 + r 2 and R 3 + R 4 each independently completes a 5- or 6-membered carbocyclic ring, or n R 1 and R 3 conjointly with the grouping --C--Y--C-- forms a carbocyclic ring with 5 or 6 carbon atoms, and Hal is halogen, n Thereby to protect X, then converting A -- Z -- COOR into a compound of the formula n n A' -- Z -- COOR n n and then treating the compound A' -- Z -- COOR to restore the group X, the improvement which comprises effecting the treatment of the compound A' -- Z -- COOR with an alkali metal compound of a complex of monovalent cobalt. The process is applicable particularly to aminocarboxylic acids including intermediates from various stages of the synthesis of penicillins and cephalosporis.

专利号:US-8044173-B2
优先权日:2005-09-13
标 题 :Asymmetric synthesis of peptides
发明人：HARWOOD LAURENCE M; YAN RAN
权利人:UNIV READING
摘要:A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR 8 , where R 8 is C 1-6 alkyl, C 6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemisation, is provided. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.