CAS: 13110-96-8; 5-Acetyl-2-Hydroxybenzoic Acid

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CAS号586-42-5 3-乙酰基苯甲酸 | CAS号50-78-2 阿司匹林 | CAS号75-36-5 乙酰氯 | CAS号69-72-7 水杨酸 | CAS号134-55-4 Benzoic acid,2-... | CAS号580-02-9 乙酰水杨酸甲酯 | CAS号16475-90-4 5-乙酰水杨酸甲酯 | CAS号7705-08-0 三氯化铁 | CAS号7446-70-0 氯化铝 | CAS号98-95-3 硝基苯 | CAS号99-93-4 对羟基苯乙酮 | CAS号108-95-2 苯酚 | CAS号36256-45-8 5-(2-溴乙酰基)-2-羟基苯甲酸甲酯 | CAS号16475-90-4 5-乙酰水杨酸甲酯 | CAS号216143-90-7 5-乙酰基-2-乙氧基苯甲酸乙酯 | CAS号68535-61-5 5-Acetyl-2-meth... | CAS号62423-71-6 5-(2-bromoacety... | CAS号51-27-4 2-羟基-5-乙基苯甲酸 | CAS号39971-36-3 5-乙酰基-2-甲氧基苯甲酸甲酯 | CAS号525-48-4 (2Z)-2-(3-carbo...

阿司匹林置于aluminum (III) Chloride体系中,用 Neat (No Solvent) 用作溶剂,化学反应 0.33H,以78%的收率获得5-乙酰基水杨酸
参考文献:水杨酸共轭异恶唑啉类似物的合成及生物学评价对免疫细胞增殖和血管生成的影响
标题:水杨酸共轭异恶唑啉类似物的合成及生物学评价对免疫细胞增殖和血管生成的影响
摘要:有丝分裂性是天然或合成化合物诱导细胞分裂或增殖的能力.合成了一系列含有异恶唑啉部分(8A-J)的水杨酸衍生物,并评估了它们针对淋巴细胞增殖和血管生成的免疫药理活性.化合物8A-J上的免疫细胞包括人外周血淋巴细胞和小鼠脾细胞促有丝分裂进行了研究体外.结果表明,在系列8A-J中,化合物8E对人和鼠淋巴细胞均显示出有效的增殖反应.化合物8E的增殖指数与参考促分裂原con A相当,并且细胞有丝分裂性是由于il-2的分泌增加所致.进行了体内cam和大鼠角膜血管生成测定,以评估该化合物对内皮细胞迁移和增殖的影响,从而推断8E也诱导了内皮细胞的增殖.该研究报告了新型有丝分裂原8E的合成免疫刺激和促血管生成活性,将来有可能将其转化为新药.
Doi:10.1016/j.Ejmech.2016.02.052

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5877296-A
优先权日:1994-06-03
标题:Process for preparing conjugates of methyltrithio antitumor agents
发明人：HAMANN PHILIP ROSS; HINMAN LOIS; HOLLANDER IRWIN
权利人:AMERICAN CYANAMID CO
摘要:This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

专利号:US-5739116-A
优先权日:1994-06-03
标题:Enediyne derivatives useful for the synthesis of conjugates of methyltrithio antitumor agents

专利号:CN-101357137-A
优先权日:2007-03-26
标题 :Use of a vitreoscilla filiformis lipopolysaccharide fraction as an agent for stimulating the synthesis of anti-microbial skin peptides

专利号:EP-0766662-A1
优先权日:1994-04-22
标 题 :Asymmetric synthesis of (r)- and (s)-arylethanolamines from iminoketones

专利号:WO-9529146-A1
优先权日:1994-04-22
标 题:Asymmetric synthesis of (r)- and (s)-arylethanolamines from iminoketones